中国药物警戒 ›› 2016, Vol. 13 ›› Issue (4): 240-244.

• 安全性评估与合理用药 • 上一篇    下一篇

红霉素及其衍生物促胃动力作用的文献计量分析

王凯1,白艳2,梅和坤1,梁蓓蓓1,白楠1,李晨1,王瑾1,王睿1   

  1. 1中国人民解放军总医院 药物临床研究中心,北京100853;
    2中国人民解放军总医院临床药理研究室,北京 100853
  • 收稿日期:2015-11-10 修回日期:2016-06-30 出版日期:2016-04-20 发布日期:2016-06-30
  • 通讯作者: 王瑾,女,硕士,副主任药师,硕导,临床药理及药物临床试验。E-mail:301jgb@sina.com。
  • 作者简介:王凯,男,本科,药师,临床药理。
  • 基金资助:
    “重大新药创制”科技重大专项个体化用药检测关键技术及相关产品研究课题(2012ZX09301003-005)。

Bibliometric Analysis of Erythromycin and Its Derivatives in Use of Promoting Gastric Motility

WANG Kai1, BAI Yan2, MEI He-kun1, LIANG Bei-bei1, BAI Nan1, LI Chen1, WANG Jin1,* WANG Rui1   

  1. 1.Center of Medicine Clinical Research, Chinese PLA General Hospital, Beijing 100853 China;
    2. Department of Pharmaceutical Care, Chinese PLA General Hospital , Beijing 100853, China
  • Received:2015-11-10 Revised:2016-06-30 Online:2016-04-20 Published:2016-06-30

摘要: 目的 用文献计量学方法统计和分析国内外应用红霉素及其衍生物促胃动力作用的研究现状,扩大红霉素临床使用范围,合理用药。方法 检索自中国知网(CNKI)建库以来到2015年8月,以及Embase,Pubmed,Web Of Science数据库中公开发表的文章,用EndNote X7软件进行整理,对其发表年份、作者、文章类型、发表期刊进行计量分析。结果 共纳入文献597篇。文献以临床研究和综述为主,其次为动物实验、病例分析、回顾性分析等。研究内容包括红霉素促胃动力作用的实验性研究、临床应用、不良反应、注意事项等。结论 红霉素及其衍生物促胃动力作用治疗胃轻瘫,促进胃排空,尤其在治疗糖尿病胃轻瘫和新生儿喂养不耐受是目前研究的热点。

关键词: 红霉素, 胃动力, 胃排空, 胃轻瘫

Abstract: Objective To use bibliometric analysis to do statistics and analyze domestic and international research status of erythromycin and its derivatives in use of promoting gastric motility, to expand the clinical use of erythromycin and assure rational drug use. Methods Embase,Pubmed,Web Of Science and CNKI were searched to collect all related literatures from beginning to August, 2015. Endnote X7 was used to sort out the type of literature, published year, first author, research institution, published journal, cited frequency and research contents with bibliometric methods. Results 597 literatures were included. The literatures were mainly clinical researches and reviews, others include animal experiments, case reports, retrospective studies, etc. Research content includes experimental study, clinical application, adverse effect, and precautions of erythromycin and its derivatives in use of promoting gastric motility. Conclusion Erythromycin and its derivatives in use of promoting gastric motility, which is in treatment of gastroparesis, promoting gastric emptying, especially in diabetic gastroparesis and neonatal feeding intolerance, have become the research hotspot.

Key words: erythromycin, gastric motility, gastric emptying, gastroparesis

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