中国药物警戒 ›› 2016, Vol. 13 ›› Issue (10): 606-608.

• 安全性评价与合理用药 • 上一篇    下一篇

基于中医药古籍的槟榔安全性及风险因素分析

侯文珍1, 杨乐2*, *, 马长华1*, *, 郭晓昕2, 任经天2, 宋海波2, 逄瑜2   

  1. 1.北京中医药大学中药学院,北京 100102;
    2.国家食品药品监督管理总局药品评价中心,北京 100045
  • 收稿日期:2016-11-23 修回日期:2016-11-23 出版日期:2016-10-20 发布日期:2016-11-23
  • 通讯作者: 杨乐,男,副主任药师,药品不良反应监测与评价。 E-mail: yangle@cdr-adr.org.cn
  • 作者简介:侯文珍,女,在读硕士,中药检验与分析。
  • 基金资助:
    国家“重大新药创制”科技重大专项（2015ZX09501004-001）; 中医药行业科研专项（201507004）

Safety and Risk Factor Analysis on Arecae Semen Base on Ancient Traditional Chinese Medicine Literatures

HOU Wen-zhen1, YANG Le2, *, MA Chang-hua1, GUO Xiao-xin2, REN Jing-tian2, SONG Hai-bo2, PANG Yu2   

  • Received:2016-11-23 Revised:2016-11-23 Online:2016-10-20 Published:2016-11-23

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摘要： 中药槟榔Arecae Semen为棕榈科植物槟榔 Areca catechu L.的干燥成熟种子,临床应用记载首见于南北朝,历代本草文献对槟榔的基原、功效、毒性、炮制、使用禁忌等多有论述。世界卫生组织国际癌症研究中心认定槟榔为一级致癌物,槟榔安全性问题日益引起社会关注。本文对历代本草中记载的槟榔毒性及用药风险因素进行了归纳分析,提出在安全性研究中应重点关注基原、配伍等对槟榔成分和不良反应的影响,为进一步研究提供线索。

关键词: 槟榔, 安全性, 文献研究

Abstract: Traditional Chinese medicine Arecae Semen is dried seed of Areca catechu L. Its clinical application records were first discovered in literatures of the Northern and Southern dynasty. The origins, efficacy, toxicity, processing and taboos of Arecae Semen have been discussed in many ancient herb literatures. The Arecae Semen was identified as a carcinogen by the International Agency for Research on Cancer(IRAC) , and the safety of Arecae Semen has increasingly attracted attention of the society. In this paper, the authors summarized and analyzed the toxicity and medication risk factors of Arecae Semen recorded in ancient herb literatures, and proposed that more attention shall be paid to the effect of the origins and the compatibility on the components and toxicity of Arecae Semen in safety studies, which provides clues for the further studies.

Key words: Arecae Semen, safety, literature study

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