中国药物警戒 ›› 2016, Vol. 13 ›› Issue (10): 587-590.

• 基础与临床研究 • 上一篇    下一篇

手术麻醉患者预防性使用5-HT3受体拮抗剂临床应用研究

赵翠红1, 张汉湘1, 王盛海1, 汤利荣1, 彭敏1, 马文霞2   

  1. 1.汉中市中心医院,陕西 汉中 723000;
    2.西安医学院第二附属医院,陕西 西安 710038
  • 收稿日期:2016-11-23 修回日期:2016-11-23 出版日期:2016-10-20 发布日期:2016-11-23
  • 作者简介:赵翠红,女,本科,副主任药师,临床合理用药。
  • 基金资助:
    陕西省卫生厅科研基金中标项目E类（2012E8）

Clinical Investigation and Analysis of Applying 5-HT3 Receptor Antagonist to Prevent PONV in Patients of Anaesthesia

ZHAO Cui-hong1, ZHANG Han-xiang1, WANG Sheng-hai1, TANG Li-rong1, PENG Min1, MA Wen-xia2   

  1. 1.Hanzhong Central Hospital, Shanxi Hanzhong 723000 China;
    2.Second Affiliated Hospital of Xi,an Medical College, Shanxi Xi, an 710038, China
  • Received:2016-11-23 Revised:2016-11-23 Online:2016-10-20 Published:2016-11-23

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摘要： 目的 通过研究手术麻醉患者5-HT3受体拮抗剂在临床使用情况,评价合理性,制定临床使用规范与体系。方法 随机调取并查阅麻醉患者病例246例,进行临床应用研究及数据统计分析。结果 本次研究进一步证实了5-HT3受体拮抗剂预防麻醉术后恶心呕吐的安全性及有效性,昂丹司琼4 mg、格拉司琼3 mg iv,围术期1次,符合临床用药安全有效、经济适当原则。结论 本次研究预防PONV使用5-HT3受体拮抗剂比例偏高,大多数椎管内麻醉无需使用阿片类药物,因此,也就无需使用5-羟色胺受体拮抗剂。

关键词: 阿片类药物, 5-羟色胺受体拮抗剂（5-HT3）, 术后恶心呕吐（PONV）

Abstract: Objective Through researching the clinical application of 5-HT3 antagonist in anesthesia patients, to analyze the rationality, which is aiming at establishing the regulation and system of clinical application of 5-HT3 antagonist. Methods The clinical application research of 5-HT3 and statistics analysis were conducted by reasearching 246 samples randomly through looking through their medical history. Results The research has further testified the effectiveness and safety of applying 5-HT3 receptor anatagonist to prevent postoperative nausea and vomiting (PONV). The specific dose conforms to the principle of clinical drug use, which is to be safe and economical. It is recommended as follows: ondansetron hydrochoride injectgion 4 mg ~ 8 mg or granisetron hydrochloride injection 3 mg by intravenous injection during perioperative period. Conclusion This research proved that there was a relative higher proportion of applying 5-HT3 receptor antagonist to prevent PONV among the participants. The research indicated that applying opioid drugs in most of the spine canal anesthesia was unnecessary, therefore, there was no necessity to apply serotonin receptor.

Key words: opioid analgesic, serotonin receptor antagonist, postoperative nausea and vomiting

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