中国药物警戒 ›› 2015, Vol. 12 ›› Issue (9): 556-559.

• 药械安全性研究 • 上一篇    下一篇

264例阿洛西林钠不良反应的文献分析

刘欣欣, 冯亚楠, 李永辉, 郭瑞锋   

  1. 河北省药品监测评价中心，河北 石家庄 050090
  • 收稿日期:2015-12-07 修回日期:2015-12-07 出版日期:2015-09-08 发布日期:2015-12-07
  • 作者简介:刘欣欣，女，本科，助理工程师，制药工程。

Literature Analysis of 264 Cases of Adverse Drug Reactions Induced by Azlocillin Sodium

LIU Xin-xin, FENG Ya-nan, LI Yong-hui, GUO Rui-feng   

  1. Center for Drug Monitoring and Evaluation of Hebei, Hebei Shijiazhuang 050090, China
  • Received:2015-12-07 Revised:2015-12-07 Online:2015-09-08 Published:2015-12-07

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摘要： 目的 探讨阿洛西林钠不良反应的一般规律特点，为临床合理用药提供参考。方法 检索中国期刊全文数据库，对2014年之前国内公开发表有关注射用阿洛西林钠264例病例文献报道进行回顾性分析。结果 儿童患者发生率高，累及系统-器官主要为皮肤及其附件损害(48.43%)、全身性损害(20.24%)、胃肠系统损害(13.01%)，严重全身性系统损害以过敏性休克、过敏样反应为主。结论 阿洛西林钠安全使用亟待加强，临床应重视阿洛西林钠的不良反应，加强用药监测，确保安全使用。

关键词: 注射用阿洛西林钠, 不良反应, 文献分析

Abstract: Objective To probe into the status, characterstics and influencing factors of ADR cases induced by azlocillin sodium, so as to provide a reference for clinical treatment. Methods Datas were collected from domestic published literatures from China Journal Full-text Database before 2014, and 264 case reports of adverse drug reactions induced by azlocillin sodium were analyzed retrospectively. Results Younger patients appeared to be with a high rate of ADR, which mainly involved skin and its appendages (48.43%), systemic damage(20.24), gastrointestinal system(13.01%), and the serious ones showed anaphylactic shock and anaphylactoid reaction.Conclusion Azlocillin sodium should be used reasonably, and the monitoring of clinical use should be strengthened to ensure the safety of medication.

Key words: azlocillin sodium, adverse drug reactions, literature analysis

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