中国药物警戒 ›› 2015, Vol. 12 ›› Issue (9): 526-527.

• 基础与临床研究 • 上一篇    下一篇

活犀角与犀角促凝血作用的研究

冯润东1, 曹蕾2, 刘蕊2, 宋冰雪2, 刘静2, 曹永孝2   

  1. 1.陕西省食品药品检验所，陕西 西安 710065;
    2.西安交通大学医学院，陕西 西安 710061
  • 收稿日期:2015-07-21 修回日期:2015-12-07 出版日期:2015-09-08 发布日期:2015-12-07

Study on Procoagulant Activity of Living Rhino Horn and Rhino Horn

FENG Run-dong1, CAO Lei2, LIU Rui2, SONG Bing-xue2, LIU Jing2, CAO Yong-xiao2   

  1. 1.Shanxi Institute for Food and Drug Control, Shanxi Xi'an 710065,China;
    2.College of Medicine, Xi'an Jiaotong University, Shanxi Xi'an 710061, China
  • Received:2015-07-21 Revised:2015-12-07 Online:2015-09-08 Published:2015-12-07

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摘要： 目的 比较活犀角与犀角的促凝血作用有无明显差异，判断活犀角是否可以作为犀角的代用品。方法 静脉注射凝血酶和氨基己酸，制造小鼠弥漫性血管内凝血(DIC)模型，研究对血小板、凝血酶时间(TT)、凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)的作用。结果 活犀角、犀角200 mg·kg-1明显增加DIC小鼠的血小板数量，明显缩短DIC模型小鼠的TT、PT和APTT。相同剂量活犀角、犀角的血小板数量和、TT、PT和APTT时间无明显差异。结论 活犀角与犀角的促凝血作用无显著差异，在促凝血作用方面活犀角可以作为犀角的代用品进行使用。

关键词: 活犀角, 犀角, 促凝血, 小鼠

Abstract: Objective To observe the difference in procoagulant activity between living rhino horn and rhino horn by the comparative research method. Methods The procoagulant activity of the living rhino horn and traditional rhino horn was evaluated in DIC model mice by intravenous thrombin and amino caproic acid. Results The living rhino horn of 100, 200 mg·kg-1 significantly increased the number of platelets and shorten TT, PT and APTT of DIC model mice. There was no difference in procoagulant activity of traditional rhino horn and the living rhino horn at the same dose. Conclusion The procoagulant activity of living rhino horn is equal to that of the traditional rhino horn,and the living rhino horn can be used as a substitute of rhino horn.

Key words: living rhino horn, rhino horn, procoagulant activity, mice

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