氨溴索对小儿法络四联症术后肺保护作用的研究

中国药物警戒 ›› 2015, Vol. 12 ›› Issue (9): 528-530.

氨溴索对小儿法络四联症术后肺保护作用的研究

罗惠丽, 黄海英, 麦惠娟

广东省深圳市龙华新区人民医院，广东深圳 518109

收稿日期:2015-05-11 修回日期:2015-12-07 出版日期:2015-09-08 发布日期:2015-12-07
作者简介:罗惠丽，女，本科，护师，儿科护理。

Research on Lung protection effects of Ambroxol in Children with Tetralogy of Fallot after Operation

LUO Hui-li, HUANG Hai-ying, MAI Hui-juan

Longhua District People's Hospital of Guangdong Shenzhen, Guangdong Shenzhen 518109, China

Received:2015-05-11 Revised:2015-12-07 Online:2015-09-08 Published:2015-12-07

摘要/Abstract

摘要： 目的探讨氨溴索在小儿法洛四联症术后的肺保护作用。方法收集2012年3月至2014年8月在本院行法洛四联症矫治术患儿62例，采用暗箱信封法，根据单双号将患者随机分为观察组(n =34)和对照组(n =34)。术毕，观察组予以氨溴索治疗;对照组患儿在相同时间给予等量生理盐水。观察两组患儿的ICU监护时间、机械通气时间、术后住院时间、术后1周内动脉血氧分压动态变化情况和治疗1周后动脉血氧分压、二氧化碳分压、氧合指数和肺部感染的发生情况。结果与对照组相比，观察组的ICU监护时间、机械通气时间、术后住院时间均具有显著差异(P < 0.05);与对照组相比，观察组患儿在术后第3、4 d动脉血氧分压变化具有显著性差异(P < 0.05);与对照组相比，观察组患儿在治疗1周后动脉血氧分压和氧合指数变化具有显著性差异(P < 0.05);住院期间，观察组患儿肺部感染率显著低于对照组(P < 0.05)。结论氨溴索用于法洛四联症矫治术后肺部功能保护，能够改善患儿氧合功能，降低呼吸道并发症的发生，促进患儿术后康复，值得在临床中推广应用。

关键词: 氨溴索, 法洛四联症, 肺保护, 疗效

Abstract: Objective To investigate the lung protective effects of ambroxol in children with tetralogy of fallot undergoing radical surgery. Methods From March 2012 to August 2014, a total of 61 children with tetralogy of fallot undergoing radical surgery were divided into normal observation group (n=34) and control group (n=34) randomly according to obscura envelope method. Ambroxol was applied in observation group at the end of operation, and normal saline was given in control group. The surgical case and breathing were recorded at each time point after operation. Results Compared with control group, the time of ICU, mechanical ventilation and hospitalization in observation group showed significant change after operation (P <0.05). Compared with control group, observation group showed significantly increased level of arterial partial pressure of oxygen on the third, fourth day after surgery(P <0.05). Compared with control group, observation group showed significant change of the arterial partial pressure of oxygen and oxygenation index in the first week after surgery (P <0.05). The incidence of infection in newborn in observation group showed obviously lower than those in the control group(P <0.05). Conclusion Ambroxol has a significant curative effect for lung protection in the patients after tetralogy of fallot surgery while avoiding respiratory complications, and it can be used widely in clinical work.

Key words: ambroxol, tetralogy of fallot, lung protection, efficacy

中图分类号:

R974.1
R969

罗惠丽, 黄海英, 麦惠娟. 氨溴索对小儿法络四联症术后肺保护作用的研究[J]. 中国药物警戒, 2015, 12(9): 528-530.

LUO Hui-li, HUANG Hai-ying, MAI Hui-juan . Research on Lung protection effects of Ambroxol in Children with Tetralogy of Fallot after Operation[J]. Chinese Journal of Pharmacovigilance, 2015, 12(9): 528-530.

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