中国药物警戒 ›› 2015, Vol. 12 ›› Issue (8): 462-463.

• 基础研究 • 上一篇    下一篇

牛蒡子苷元注射液对SD大鼠急性毒性研究

刘松江1, 刘松燕2   

  1. 1. 临沂市沂水中心医院,山东 临沂 276400;
    2. 鲁南制药集团股份有限公司新药安评中心,山东 临沂 273400
  • 收稿日期:2015-09-02 修回日期:2015-09-02 出版日期:2015-08-08 发布日期:2015-09-02
  • 通讯作者: 刘松燕,女,本科,工程师,药理毒理与临床研究。E-mail: shuangyan8365@163.com
  • 作者简介:刘松江,男,本科,副主任中医师,中医内科学及中医临床药理学研究。

Study on Acute Toxicity of Arctigenin Injection in SD Rats

LIU Song-jiang1, LIU Song-yan2   

  1. 1. Linyi Yishui Central Hospital, Shandong Linyi 276400, China;
    2. Center for New Drug Safety Evaluation of Lunan Pharmaceutical, Shandong Linyi 273400, China
  • Received:2015-09-02 Revised:2015-09-02 Online:2015-08-08 Published:2015-09-02

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摘要： 目的 通过上下法（UDP）观察牛蒡子苷元注射液大鼠静脉注射及皮下注射毒性反应。方法 UDP试验分静脉注射和皮下注射两组,根据AOT425 StatPgm设定程序进行试验。健康SD大鼠40只,各组20只。结果 静脉注射LD50为8.9 mg·kg-1,95%置信区间6.6~17.5 g·kg-1,皮下注射LD50为227.3 mg·kg-1,95%置信区间166.3~348 mg·kg-1。结论 牛蒡子苷元注射液静脉注射毒性较大,皮下注射较为安全。

关键词: 牛蒡子苷元, 上下法, 急性毒性

Abstract: Objective To study the acute toxicity of arctigenin injection in rats by Up-and-Down Procedure(UDP). Methods The UDP test includes intravenous injection group and subcutaneous injection group, according to the AOT425 StatPgm administration. 40 healthy SD rats were divided into two groups, 20 each. Results LD50 of intravenous injection group is 8.9 mg·kg-1, the 95% confidence interval is 6.6~17.5 mg·kg-1. LD50 of subcutaneous injection group is 227.3 mg·kg-1, the 95% confidence interval is 166.3~348 mg·kg-1. Conclusion In this study, arctigenin intravenous injection has greater toxicity, subcutaneous injection is relatively safe.

Key words: arctigenin, Up-and-Down Procedure, acute toxicity

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