阿托伐他汀强化治疗对脑血管介入诊疗术后造影剂肾病的影响

摘要/Abstract

摘要： 目的探讨阿托伐他汀强化治疗对脑血管介入术后造影剂肾病（CIN）的影响。方法选择 2014年 7月～ 2014年 12月我院收治的 95例行脑血管介入术诊疗的脑血管病患者为研究对象，随机分为观察组（49例）和对照组（46例）。术前 3天及术后，对照组口服阿托伐他汀 20 mg·d-1治疗，观察组分别口服阿托伐他汀 80 mg·d-1和 40 mg·d-1强化治疗，分别于手术前 24h、术后 72h监测血清肌酐（Scr）、肌酐清除率（Ccr）、 β2-微球蛋白（β2-MG）、胱抑素 C（CYS-C）、超敏 C反应蛋白（hs-CRP）水平。结果观察组患者术后肾功能指标和 hs-CRP指标改变幅度优于对照组，差异具有统计学意义（P＜0.05）。结论脑血管介入术前给予阿托伐他汀强化治疗可减轻肾损害，且安全可行。机制与其抑制炎症因子有关。

关键词: 阿托伐他汀, 造影剂肾病, 脑血管介入术, 预防

Abstract: Objective To investigate clinical effects of atrovastatin intensive treatment on contrast-induced nephropathy (CIN) after cerebral vascular interventional therapy援 Methods 95 cases of patients with cerebral vascular diseases requring cerebral vascular interventional therapy in our hospital from July to December 2014 were divided into the observation group (n=49) and control group (n=46). 72 h before operation and after operation, the observation group was given atrovastatin intensive treatment(80 mg, 40 mg), the control group was given atrovastatin treatment (20 mg). The SCR (serum creatinine), CCR (endogenous creatinine clearance), β2-MG( β2-micro globulin), CYS-C (plasma cystatin), hs-CRP (high sensitivity C reactive protein) of two groups were analyzed 24 h before operation and 72h after operation. Results The postoperative renal function and hs-CRP improvement of the observation group was better than that of the control group(P < 0.05). Conclusion The atrovastatin intensive treatment before cerebral vascular interventional therapy can reduce renal damage and is safe, which may be achieved by inhibition of inflammation factor.

Key words: atrovastatin, contrast-induced nephropathy, cerebral vascular interventional therapy, prevention

中图分类号:

R965

林浩海,秦超,*,程道宾,段松波,魏晓勇. 阿托伐他汀强化治疗对脑血管介入诊疗术后造影剂肾病的影响[J]. 中国药物警戒, 2015, 12(5): 267-270.

LIN Hao-hai ,QIN Chao*,CHENG Dao-bin ,DUAN Song-bo ,WEI Xiao-yong. Clinical Effects of Atrovastatin Intensive Treatment on Contrast-Induced Nephropathy after Cerebral Vascular Interventional Therapy[J]. Chinese Journal of Pharmacovigilance, 2015, 12(5): 267-270.

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