中国药物警戒 ›› 2021, Vol. 18 ›› Issue (5): 464-468.
DOI: 10.19803/j.1672-8629.2021.05.13

• 安全与合理用药 • 上一篇    下一篇

2015~2018年深圳市坪山区疑似预防接种异常反应监测报告分析

陈爱宏1, 尹强兵2, 李华丹1, 吴能简1,*   

  1. 1深圳市坪山区疾病预防控制中心,广东 深圳 518118;
    2深圳市罗湖区疾病预防控制中心,广东 深圳 518000
  • 收稿日期:2019-12-10 出版日期:2021-05-15 发布日期:2021-05-12
  • 通讯作者: *吴能简,男,硕士,主任医师,疾病预防控制与管理。E-mail:1914214330@qq.com
  • 作者简介:陈爱宏,男,本科,主管医师,免疫规划管理。

Analysis of Monitoring Reports on Suspected Adverse Events Following Immunization in Pingshan District Shenzhen City during 2015~2018

Chen Aihong1, Yin Qiangbing2, Li Huadan1, Wu Nengjian1,*   

  1. 1Pingshan Center for Disease Control and Prevention, Shenzhen Guangdong 518118, China;
    2Luohu Center for Disease Control and Prevention, Shenzhen Guangdong 518000, China
  • Received:2019-12-10 Online:2021-05-15 Published:2021-05-12

PDF (PC)

108

摘要： 目的 分析深圳市坪山区2015~2018年疑似预防接种异常反应（AEFI）报告数据特征,初步评价AEFI监测系统运转情况和AEFI流行特征。方法 通过《中国免疫规划信息管理系统》收集深圳市坪山区2015~2018年报告的AEFI个案信息,结合各类疫苗实种统计数据,采用描述性流行病学方法进行数据分析。结果 深圳市坪山区年度接种门诊报告覆盖率达100.0%,2015~2018年共报告AEFI 318例,累计报告发生率为20.35/10万剂次。318例AEFI中,接种一类疫苗的占69.5%,接种二类疫苗的占30.5%。报告AEFI最多的疫苗是无细胞百白破疫苗,占20.4%;报告发生率最高的疫苗为23价肺炎疫苗,为162.14/10万剂次。90.3%AEFI发生于疫苗接种后24 h内,以一般反应居多,占71.1%,其次为异常反应,占27.4%,所有反应均治愈或好转。结论 深圳市坪山区AEFI监测系统运转正常,工作敏感性逐步提高,但仍需不断完善预防接种工作机制,提高AEFI 监测工作质量及严重AEFI应急处置能力。

关键词: 疑似预防接种异常反应, 疫苗, 监测

Abstract: Objective To analyze the characteristics of adverse events following immunization(AEFI) between 2015 and 2018 in Pingshan District, Shenzhen, and to evaluate the operation of the AEFI surveillance system and epidemiology of AEFI. Methods Cases of AEFI in Pingshan District, Shenzhen were collected between 2015 and 2018 via the National Immunization Program Information Management System as well as the actual vaccination data were analyzed by descriptive epidemiological methods. Results The annual coverage rate of clinical vaccination was 100.0%. A total of 318 cases of AEFI were reported between 2015 and 2018, and the cumulative report rate was 20.35/100,000 doses. Among the 318 cases of AEFI, 69.5% were vaccinated with the first class vaccines, and 30.5% with the second class vaccines. The rate of AEFI was the highest with DaTP(20.4%), and the most frequently reported vaccine was PPV23 with 162.14/100,000 doses. 90.3% of AEFI occurred within 24 hours of vaccination. Common reactions were dominating (71.1%), followed by adverse reactions (27.4%). All these cases were cured or improved. Conclusion The AEFI surveillance system in Pingshan is operating smoothly and the sensitivity is gradually improved. However, it is still necessary to improve the mechanism of vaccination, the quality of data on AEFI monitoring and emergency response to severe AEFI.

Key words: suspected adverse events following immunization, vaccination, monitoring

中图分类号: