中国药物警戒 ›› 2015, Vol. 12 ›› Issue (3): 172-174.

• 药械安全性研究 • 上一篇    下一篇

44例注射用脂溶性维生素不良反应文献分析

易丹   

  1. 株洲市中心医院药物临床试验机构，湖南 株洲 412000
  • 收稿日期:2014-12-01 修回日期:2015-07-28 出版日期:2015-03-08 发布日期:2015-07-28
  • 作者简介:易丹，女，硕士，主任技师，脂溶性维生素监测。

Literature Analysis of 44 Cases of Adverse Drug Reactions Induced by Fat-soluble Vitamin for Injection

YI Dan   

  1. First Hospital of Zhuzhou;
    Hunan Zhuzhou 412000, China
  • Received:2014-12-01 Revised:2015-07-28 Online:2015-03-08 Published:2015-07-28

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摘要： 目的 探讨注射用脂溶性维生素所致不良反应的一般规律和特点，为临床合理用药提供参考。方法 检索1994～2014年中国期刊全文数据库报道的注射用脂溶性维生素所致不良反应案例，并进行统计与分析。结果 注射用脂溶性维生素所致不良反应多在用药过程中30 min内发生。不良反应累及机体多个系统，临床表现复杂多样，主要表现为过敏反应，严重者可出现呼吸困难或过敏性休克。结论 临床医师和药师应重视注射用脂溶性维生素的不良反应，坚持合理用药。

关键词: 脂溶性维生素, 不良反应, 文献, 分析

Abstract: Objective To explore the general characteristics of adverse drug reactions(ADR) induced by Fat-soluble vitamin for injection so as to provide references for rational clinical drug use. Methods ADR cases induced by Fat-soluble vitamin for injection reported in domestic medical journals during 1994～2014 were collected and analyzed statistically. Results ADR induced by Fat-soluble vitamin for injection often occurred within 30 min after injection. ADR could involve multiple organs and systems, and clinical manifestations were various, mainly allergic reactions. Severe allergic reactions could manifest dyspnoea and anaphylactic shock. Conclusion Clinical physicians and pharmacists should pay attention to the ADR induced by Fat-soluble vitamin for injection and persist in rational drug use.

Key words: Fat-soluble vitamin for injection, adverse drug reactions, literature, analysis

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