中国药物警戒 ›› 2015, Vol. 12 ›› Issue (10): 614-617.

• 质量与工艺研究 • 上一篇    下一篇

基于ICP-MS的金银花和山银花中20种重金属及微量元素分析

许顺贵, 刘春光   

  1. 武警北京市总队医院药剂科，北京100027
  • 收稿日期:2015-06-30 修回日期:2015-12-07 出版日期:2015-10-08 发布日期:2015-12-07
  • 通讯作者: 刘春光，女，硕士，副主任药师，医院药学。E-mail：liuchunguangBJS@163.com
  • 作者简介:许顺贵，男，本科，主管药师，药学。

Determination of 20 Heavy Metals and Trace Elements in Lonicera Japonica and Lonicera Hypoglauca by ICP-MS

XU Shun-gui, LIU Chun-guang   

  1. Beijing Armed Police Corps Hospital, Beijing 100027, China
  • Received:2015-06-30 Revised:2015-12-07 Online:2015-10-08 Published:2015-12-07

PDF (PC)

136

摘要： 目的 建立金银花和山银花两种药材中Pb、Cu、As、Cd、Hg、Mn、Ni、Tl等20种元素含量测定方法。方法 样品经微波消解后，以Ge，In两种元素作为内标，电感耦合等离子体质谱仪进行分析。结果 各元素的线性关系良好;方法检出限为0.004 μg·L-1~0.071 μg·L-1;精密度和准确度良好;回收率在80%～100%的范围内。结论 测量方法灵敏度高，专属性好，可为两种药材鉴别以及质量控制提供参考。

关键词: 金银花, 山银花, 电感耦合等离子体质谱, 微波消解, 元素分析

Abstract: Objective To develop a method for the determination of a total of 20 elements such as plumbum (Pb), copper (Cu), arsenic (As), cadmium (Cd), mercury (Hg), manganese (Mn), nickel (Ni), thalliu (Tl) in Lonicera japonica and Lonicera hypoglauca. Methods The samples were digested by microwave-assisted method and then chose appropriate determination parameters of ICP-MS, using Ge and In as the internal standard. Results All the correlation coefficients exceeded 0.9993, showing good linearities over the concentration range. The lower limit of detection of the assay ranged from 0.004 to 0.071 μg·L-1. The method exhibited good precision and accuracy, while the recoveries ranged from 80% to 100%. Conclusion The method is simple, accurate and highly sensitive, successfully applied to rapid monitoring the multi-elements in Lonicera japonica and Lonicera hypoglauca for the quality control and identification.

Key words: Lonicera japonica, Lonicera hypoglauca, inductively coupled plasma mass spectrometer (ICP-MS), microwaves digest, element analysis

中图分类号: