中国药物警戒 ›› 2015, Vol. 12 ›› Issue (1): 41-44.

• 药械安全性研究 • 上一篇    下一篇

阿奇霉素致心血管系统不良反应报告分析

李宗1,沈晓华1,吴泽晗2   

  1. 1福建省药品不良反应监测中心，福建 福州 350003
    2福建中医药大学，福建 福州 350108
  • 收稿日期:2014-11-17 出版日期:2015-01-08 发布日期:2015-07-28
  • 作者简介:李宗，男，主任药师，药品不良反应监测。

Analysis of Adverse Drug Reactions about Cardiovascular System Caused by Azithromycin

LI Zong1,SHEN Xiao-hua1,WU Ze-han2   

  1. 1Center for ADR Monitoring of Fujian, Fujian Fuzhou 350003, China;
    2Fujian University of Traditional Chinese Medicine, Fujian Fuzhou 350108, China
  • Received:2014-11-17 Online:2015-01-08 Published:2015-07-28

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摘要： 目的 探讨阿奇霉素致心血管系统不良反应/事件（ADR/ADE）的特点和规律。方法 采用回顾性研究方法 ，对1 321例阿奇霉素致心血管系统的ADR/ADE报告进行统计分析。结果 致心血管系统的ADR/ADE主要表现为心悸、胸闷、心动过速、心律失常等；静脉给药方式的风险较为突出；不良反应发生时间主要集中在用药后30 min内。结论 有必要就阿奇霉素对特定人群的安全性以及对心血管系统的不良反应进行再评价，并在此基础上对药品使用说明书作出修改，对其静脉给药方式的安全性作出必要的警示。

关键词: 阿奇霉素, 心血管系统, 不良反应/事件

Abstract: Objection To explore the characters of the adverse reactions/events about cardiovascular system caused by azithromycin. Methods 1 321 reports of the adverse reactions/events about cardiovascular system caused by azithromycin were analyzed via retrospective study. Results Azithromycin may lead to adverse reactions such as palpitations, chest tightness, tachycardia,etc. The risk of intravenous delivery was dominant. The adverse reactions about cardiovascular system occurred within 30 min. Conclusion It is necessary to reevaluate the risk of azithromycin for specific populations of safety and adverse effects about cardiovascular system. On this basis, modify the drug instructions and make the necessary warning for the safety of its intravenous administration.

Key words: azithromycin, cardiovascular system, adverse reaction/event

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