中国药物警戒 ›› 2014, Vol. 11 ›› Issue (5): 297-300.

• 药械安全性研究 • 上一篇    下一篇

86例别嘌醇片致不良反应/事件的文献分析

谭莉莉   

  1. 山东枣庄市峄城区人民医院,山东 枣庄 277300
  • 收稿日期:2016-02-03 修回日期:2016-02-03 出版日期:2014-05-08 发布日期:2016-03-02
  • 作者简介:谭莉莉,女,本科,主管药师,医院药学。

Literature Analysis of 86 Cases of Adverse Reaction /Event Caused by Allopurinol Tablet

TAN Li-li   

  1. People's Hospital of Yicheng District, Shandong Zaozhuang 277300, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-05-08 Published:2016-03-02

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摘要： 目的探讨别嘌醇片所致不良反应/事件（ADR/ADE）的临床特征、相关规律及机制,为临床安全合理用药提供参考。方法检索中国生物医学文献数据库、中国期刊全文数据库及中文科技期刊全文数据库1994~2013年关于别嘌醇片所致ADR/ADE的个案报道,并进行统计分析。结果得到符合标准的病例86例,不良反应报告中男性明显多于女性;以中老年患者为主,61~70岁患者构成比最高（27例,31.40%）;不良反应主要集中在用药后1个月内发生（79例,91.86%）;不良反应可累及多个系统-器官,出现很多新的严重的不良反应甚至死亡;不良反应以皮肤系统构成比最高（74例,61.67%）,在皮肤系统损害中主要表现为重症药疹（36例,48.65%）,预后效果较差。结论临床医师、药师应重视并掌握别嘌醇片致不良反应的规律和特点,安全用药,并加强临床监测,以减少不良反应的发生。

关键词: 别嘌醇片, 不良反应/事件, 文献分析

Abstract: ObjectiveTo explore the clinical features, correlation rules and mechanism of ADR/ADE caused by allopurinol tablet, and to provide a reference for clinical rational use of drugs. MethodsRetrieving CBM Database, CNKI and Chinese Periodical Full-text Database, literatures on ADR/ADE caused by allopurinol tablet during 1994~2013 were statistically analyzed. Results86 ADR/ADE cases were enrolled. The number of male patients was more than female; the 61~70 years old patients were with the highest incidence; the majority of ADR/ADE cases broke out within 1 month after medication(79 cases,91.86%); the adverse reactions involved many systems and organs, and there were some new and severe ADR/ADE cases, even some were dead; the main manifestation of ADR/ADE was skin system

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