中国药物警戒 ›› 2014, Vol. 11 ›› Issue (5): 301-303.

• 药械安全性研究 • 上一篇    下一篇

33例利奈唑胺致血小板减少的文献分析

黄丽, 陆向红, 罗佳   

  1. 株洲市中心医院药剂科,湖南 株洲 412000
  • 收稿日期:2016-02-03 修回日期:2016-02-03 出版日期:2014-05-08 发布日期:2016-03-02
  • 作者简介:黄丽,女,硕士,药师,临床药学。

Literature Analysis of 33 Cases of Thrombocytopenia Induced by Linezolid

HUANG Li, LU Xiang-hong, LUO Jia   

  1. Department of Pharmacy, Zhuzhou Central Hospital, Hunan Zhuzhou 412000, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-05-08 Published:2016-03-02

PDF (PC)

306

摘要： 目的通过对利奈唑胺致血小板减少的文献进行分析,探讨其引起血小板减少的规律,为临床合理应用利奈唑胺提供参考。方法以“利奈唑胺”、“血小板减少”、“不良反应”为关键词对2001~2012年中国知网（CNKI）数据库和维普医学期刊数据库文献进行检索,对其中涉及利奈唑胺致血小板减少的19篇文献中报道的33例病例报告进行统计与分析。结果男性25例,女性8例,60岁以上的老年人23例。高龄、基础血小板值偏低（≤200×109·L-1）、疗程长属利奈唑胺致血小板减少的高危因素。经停药、采取相应治疗措施大部分可于7~14d后恢复正常。结论应重视利奈唑胺致血小板减少的不良反应,在应用过程中注意观察,监测血常规,做到及早发现、正确处理。

关键词: 药品不良反应, 利奈唑胺, 血小板减少

Abstract: Objective To study the features of thrombocytopenia induced by linezolid through literature analysis and provide reference for clinical rational use of linezolid. Methods To collect literatures from 2001 to 2012 reported in China National Knowledge Infrastructure(CNKI) and VIP medical journal database with linezolid,thrombocytopenia and ADR as key words,and to analyze statistically the 33 ADR cases involved in 19 articles of linezolid inducing thrombocytopenia. Results Twenty five cases were male, 8 cases were female, 23 cases were more than 60 years old. The high-risk factors of thrombocytopenia were advanced age,low baseline platelet count(≤200×109·L-1) and long course of treatment. Most cases returned to normal after drug withdrawal and corresponding treatments in 7~14 days. Conclusion In order to detect earlier and deal correctly,we should pay more attention to the ADR of linezolid inducing thrombocytopenia.It needs to observe closely and monitor blood routine examination during application.

Key words: adverse drug reaction(ADR), linezolid, thrombocytopenia

中图分类号: