中国药物警戒 ›› 2014, Vol. 11 ›› Issue (4): 229-231.

• 药械安全性研究 • 上一篇    下一篇

505例注射用七叶皂苷钠不良反应的文献分析

谢晓燕1, 李清芳1, 张惠霞2*, 王丽2   

  1. 1开封市药品不良反应监测中心,河南 开封 475000;
    2河南省食品药品评价中心,河南 郑州 450004
  • 收稿日期:2013-11-19 修回日期:2016-02-03 出版日期:2014-04-08 发布日期:2016-02-03
  • 作者简介:谢晓燕,女,硕士,药师,药品不良反应监测。

Literature Analysis of 505 Cases of Adverse Drug Reactions Induced by Sodium Aescinate for Injection

XIE Xiao-yan1, LI Qing-fang1, ZHANG Hui-xia2, *, WANG Li2   

  1. 1KaiFeng Center for ADR Monitoring,Henan Kaifeng 475000, China;
    2Food and Drug Reevaluation Center of Henan Province,Henan Zhengzhou 450004, China
  • Received:2013-11-19 Revised:2016-02-03 Online:2014-04-08 Published:2016-02-03

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摘要： 目的探讨注射用七叶皂苷钠致不良反应的一般规律、特点及相关风险因素,为临床安全用药提供参考。方法以“七叶皂苷”、“不良反应”等为检索词,检索中国生物医学文献数据库、中国期刊全文专题数据库、中国科技期刊数据库、万方数据库,按纳入与排除标准共纳入47篇文献,进行资料提取和统计分析。结果注射用七叶皂苷钠不良反应可累及多个系统-器官,以静脉炎、过敏反应最为常见,严重者可致过敏性休克、肝肾损害等。结论重视注射用七叶皂苷钠引发的不良反应,密切防范不良反应的发生,确保临床用药安全。

关键词: 注射用七叶皂苷钠, 不良反应/事件, 分析

Abstract: ObjectiveTo investigate the general rule, characteristics and risks of adverse drug reaction(ADR) induced by sodium aescinate injection, in order to provide theoretic support for drug Safety in clinical administration. MethodsUse "Sodium aescinate"and"adverse drug reaction"as key words, searching and retrieving references in the following databases as CBM, CNKI, VIP and WanFang Data. 47 references which met the inclusion and exclusion criteria were extracted and analyzed. ResultsThe adverse reactions may involve multiple organs and systems, The most common reactions are phlebitis, allergic reaction,etc. Severe cases can cause anaphylactic shock, renal failure, liver and kidney damage, and skin necrosis. ConclusionIt is important to pay attention to the adverse reactions caused by sodium aescinate when administrating by injection, preventing severe adverse drug reactions from happening, and ensuring the Safety of clinical administration.

Key words: sodium aescinate for injection, adverse drug reaction/event, analysis

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