中国药物警戒 ›› 2014, Vol. 11 ›› Issue (3): 172-175.
DOI: DOI

• 药械安全性研究 • 上一篇    下一篇

325例儿童药品不良反应报告分析

孙健1, 温庆辉2, 马琰岩1,张立富 1,3 范斌1, 吕俊海1*, *   

  1. 湖南省儿童医院,湖南 长沙 410007
  • 收稿日期:2013-07-29 修回日期:2016-02-03 出版日期:2014-03-08 发布日期:2016-02-03
  • 作者简介:何莉梅,女,药师,硕士,临床药学及相关研究。

Analysis of 325 Adverse Reaction Reports of Children

HE Li-mei, PENG Cui-ying, ZHANG Hai-xia, HE Zhou-kang   

  1. Hunan Children's Hospital, Hunan Changsha 410007, China
  • Received:2013-07-29 Revised:2016-02-03 Online:2014-03-08 Published:2016-02-03

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摘要： 目的分析我院儿童药品不良反应（ADR）发生的情况以及引发ADR的相关因素,为临床合理用药及正确评价ADR的发生提供参考。方法对我院收集的2010~2012年的325例ADR进行分类汇总,并加以分析。结果在325例儿童ADR中,男性患儿占230例（70.77%）,女性患儿占95例（29.23%）。静脉给药者居多,占296例（91.08%）。抗微生物药引起的ADR居首位,共40种抗微生物药物,引起156例ADR,占总例数的48.00%。皮肤及其附件损害是ADR最主要的临床表现,占总例次的77.41%。结论ADR的发生与给药途径、药品种类等多种因素相关,应加强ADR的监测及相关知识的宣传,以减少和避免ADR的发生。

关键词: 药品不良反应, 合理用药, 儿童

Abstract: ObjectiveTo study the occurrence of children adverse drug reactions(ADR) in our hospital and its relevant factors in order to improve the rational drug use level in clinic. Methods325 ADR cases collected in our hospital from 2010 to 2012 were categorized and statistically analyzed. ResultsAmong 325 ADR cases, 230 cases(70.77%) were male, and only 95 cases(29.23%) were female. Most of the cases were induced by intravenous injection, accounting for 91.08%(296 cases). 156 cases(48.00%) were induced by 40 kinds of antimicrobials, which were the first category of drugs to cause ADR. The injury of skin and its appendants was the most common ADR, which occupied 77.41%. ConclusionThe occurrence of ADR was related to many factors, such as administration routine and drug varieties. In order to reduce and avoid the occurrence of ADR, we should strengthen the monitoring and publicize ADR knowledge.

Key words: adverse drug reaction(ADR), rational drug use, children

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