中国药物警戒 ›› 2014, Vol. 11 ›› Issue (3): 129-133.

• 基础及临床研究 •    下一篇

术竭异位安胶囊对大鼠的长期毒性实验研究

张雪梅1, 骞秀芳2*, *   

  1. 1武警北京总队医院药剂科,北京 100027;
    2武警北京总队第二医院药剂科,北京 100027
  • 收稿日期:2014-01-06 修回日期:2016-02-03 出版日期:2014-03-08 发布日期:2016-02-03
  • 作者简介:张雪梅,女,主管药师,医院药学。

Long-term Toxicity of Zhujie Yiweian Capsule in Rats

ZHANG Xue-mei1, QIAN Xiu-fang2, *   

  1. 1Department of Pharmacy, Beijing Armed Police Forces Hospital, Beijing 100027, China;
    2Department of Pharmacy, the Second Hospital of Beijing Armed Police Forces, Beijing 100027, China
  • Received:2014-01-06 Revised:2016-02-03 Online:2014-03-08 Published:2016-02-03

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摘要： 目的观察术竭异位安胶囊连续给药后对大鼠的毒性反应。方法大鼠分为术竭异位安胶囊高、中、低剂量组（分别为生药150 g·kg-1、85 g·kg-1、20 g·kg-1）和溶媒对照组,每组20只。连续灌胃给药26周,观察大鼠一般状况、体重和摄食量变化。于末次给药后和停药4周后分别取部分大鼠,检测血液学指标、血液生化学指标、脏器系数及病理组织学改变。结果与溶媒对照组比较,各给药组对大鼠的生长发育无显著影响;血液学检查中,术竭异位安胶囊可使血小板、白细胞增多,减少红细胞,显著延长凝血酶原时间,原因与该药抗血栓的药理作用有关;血液生化检查中,可降低天门冬氨酸氨基转移酶含量,升高总蛋白和尿素氮;术竭异位安胶囊可使肝脏系数和脾脏系数升高;停药后上述指标均可恢复至正常范围;病理组织学检查则未见明显病变。恢复期未见药物引起的迟发性毒性反应。结论术竭异位安胶囊（生药20 g·kg-1~150 g·kg-1）对大鼠长期给药,未见明显毒性反应。

关键词: 术竭异位安胶囊, 大鼠, 长期毒性

Abstract: ObjectiveTo investigate the long-term toxicity reaction in rats given Zhujie Yiweian Capsule(ZYC) continuously. MethodsSD rats were divided into 4 groups randomly(n=20), namely normal control, ZYC high, medium and low dose groups(150, 85 and 20 g·kg-1, respectively). ZYC was orally administered for 26 weeks. The body weight and food intake were observed and calculated during the administration. The hematology and blood biochemistry analysis were carried out, and organ histopathological changes were also observed under the microscope at the end of the administration and 4 weeks after the administration, respectively. ResultsThe appearance and behavior and body weight in rats of ZYC groups showed no significant difference compared to the normal control group. In hematology analysis, ZYC increased platelet and white blood cell count, decreased red blood cell count and remarkably prolonged the prothrombin time, which should be associated with the antithrombotic effect of ZYC. In biochemistry analysis, ZYC significantly inhibited AST, increased TP and BUN contents. In addition, ZYC elevated the liver and spleen coefficients. In histopathological observation, ZYC showed no apparent influence in organs of rats. No delayed toxicity reaction was showed 4 weeks after the administration. ConclusionZYC(20 to 150 g·kg-1) shows no obvious toxicity in rats for long-term administration.

Key words: Zhujie yiweian capsule, rats, long-term toxicity

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