中国药物警戒 ›› 2014, Vol. 11 ›› Issue (1): 54-56.

• 医院药事管理与合理用药 • 上一篇    下一篇

运用HPLC及液相色谱质谱联用技术分析临床药品事件

周宁1,高钧1*,*,王洪亮2,李琳2   

  1. 1北京博爱医院药剂科,北京100068;
    2中国医学科学院药物研究所,北京 100050
  • 收稿日期:2016-02-03 修回日期:2016-02-03 出版日期:2014-01-08 发布日期:2016-02-03
  • 通讯作者: 高钧,男,副主任药师,临床药学。E-mail:gaojunmy@sina.com
  • 作者简介:周宁,女,主管药师,临床药学。

Analysis of Clinical Drug Event by HPLC and HPLC-MS

ZHOU Ning1, GAO Jun1, *, WANG Hong-liang2, LI Lin2   

  1. 1Beijing Bo-ai Hospital, Beijing 100068, China;
    2Institute of Materia Medica, Chinese Academy of Medical Science, Beijing 100050, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-01-08 Published:2016-02-03

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摘要： 目的采用药学技术分析奥美拉唑变色事件的原因。方法HPLC及液相色谱质谱联用技术定性测定变色药液中的反应物质。结果该变色反应为奥美拉唑与盐酸氨溴索反应所致,氨溴索通过小壶入奥美拉唑通路,并未进入患者体内。结论运用药学技术可以辅助还原药品事件,尽快弄清事件为药品本身质量问题还是操作失误所致。

关键词: HPLC, 液相色谱质谱联用技术, 药品事件

Abstract: ObjectiveTo analyze the color change event of omeprazole by pharmaceutical technology. MethodsThe contents of the mixed solution were determined using HPLC and HPLC-MS methods. ResultsThe result showed that omeprazole was mixed with ambroxolhydrochloride, which caused the color change reaction. No mixed solution was infused into the patient. ConclusionHPLC and HPLC-MS are applicable methods in the analysis of drug event. This study might serve as a reference for dealing with events alike.

Key words: HPLC, HPLC-MS, drug event

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