中国药物警戒 ›› 2014, Vol. 11 ›› Issue (1): 35-38.

• 药械安全性研究 • 上一篇    下一篇

药品不良反应的食物因素

宋海波,郭晓昕,任经天,杜晓曦*   

  1. 国家食品药品监督管理总局药品评价中心,北京 100045
  • 收稿日期:2016-02-03 修回日期:2016-02-03 出版日期:2014-01-08 发布日期:2016-02-03
  • 通讯作者: 杜晓曦,女,主任药师,药品技术评价与药品风险管理。E-mail:duxiaoxi@cdr.gov.cn
  • 作者简介:宋海波,男,博士,副主任药师,临床药理研究。

The Diet Factor of Adverse Drug Reactions

SONG Hai-bo, GUO Xiao-xin, REN Jing-tian DU Xiao-xi*   

  1. Center for Drug Reevaluation, CFDA, Beijing 100045, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-01-08 Published:2016-02-03

摘要: 目的探讨药品不良反应的食物因素。方法收集国内外与食物有关的药品不良反应文献报道,分析其发生机制。结果食物可影响药物的理化性质及药动学特性,可协同或拮抗药物的药效和毒性。食物对药物的影响可能与食物中某种或多种营养成分有关。结论应加强药品不良反应中食物因素的研究,注意分析总结食物对药物疗效及安全性的影响,为临床安全用药提供数据支持。

关键词: 药品不良反应, 食物, 相互作用

Abstract: Objective To explore the diet factor of adverse drug reactions. Methods The domestic and foreign diet-related adverse drug reactions reported in the literature were collected, and the mechanism was analyzed. Results Diet can affect drug physicochemical properties and pharmacokinetic properties. The synergistic or antagonistic interactions between diet and drug may affect the efficacy and toxicity of drugs. The diet-related adverse drug reactions may be associated with certain nutrient or multiple nutrients in the diet. Conclusion In order to provide data to support the clinical safety of medication, the research of diet factor of adverse drug reactions should be strengthened, and the impact of diet on drug efficacy and safety should be analyzed and summarized.

Key words: adverse drug reactions, diet, interaction

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