中国药物警戒 ›› 2013, Vol. 10 ›› Issue (9): 567-570.

• 医院药事管理与合理用药 • 上一篇    下一篇

丹参注射液与输液配伍的稳定性研究

林小明1, 黄敏2,朱坚3   

  1. 1.广西贵港市人民医院,广西贵港537100；
    2.广西中医药大学第一附属医院,广西南宁530023；
    3.广西民族医院,广西南宁530001
  • 收稿日期:2013-04-15 修回日期:2016-03-09 出版日期:2013-09-08 发布日期:2016-03-09
  • 作者简介:林小明,男,本科,副主任中药师,临床药学。

Study of Compatible Stability on Salvia Injection and Transfusion

LIN Xiao -ming1, HUANG Min2 ,ZHU Jian3   

  1. 1.People's Hospital of Guigang City, Guangxi Guigang 537100, China;
    2.The First Affiliated Hospital of Guangxi Traditional Chinese Medicine University, Guangxi Nanning 530023, China;
    3.Guangxi National Hospital,Guangxi Nanning 530001, China
  • Received:2013-04-15 Revised:2016-03-09 Online:2013-09-08 Published:2016-03-09

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摘要： 目的 考察多因素对丹参注射液与输液配伍后稳定性的影响,优选出最佳配伍方案。方法 采用正交试验,以溶液中微粒、原儿茶醛含量为观察指标,用GWF-5J 型微粒分析仪测定溶液中不溶性微粒数,用HPLC 法测定溶液中原儿茶醛含量。结果 配伍温度、放置时间对溶液中原儿茶醛的含量有显著性影响；剂量对溶液中微粒的含量有显著性影响。结论 丹参注射液最佳配伍条件为25℃、剂量20mL、放置2h、与100 mL 氯化钠注射配伍。

关键词: 丹参注射液, 不溶性微粒, 原儿茶醛, 正交实验

Abstract: Objective To investigate the effect of multiple factors on compatible stability in salvia injection and transfusion so as to achieve the optimal program. Methods The particle content was measured by GWF-5J particle analyzer with orthogonal test, and the particles in solution and protocatechuic aldehyde content were used as indicators. The protocatechuic aldehyde content in solution was determined by HPLC. Results Effect of compatible temperature and stored time on protocatechuic aldehyde content was statistically significant. In addition, effect of dose on particle content in solution was statistically significant. Conclusion The optimal compatible match of salvia injection was to combine with 100 mL sodium chloride injection at 25℃ for 2 hours.

Key words: salvia injection, insoluble particle, protocatechuic aldehyde, orthogonal test

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