中国药物警戒 ›› 2012, Vol. 9 ›› Issue (9): 573-576.

• 英文专栏 • 上一篇    

红景天多糖对体外正常人T淋巴细胞活性和体外人胃癌细胞增殖的影响

张红旭, 韩枫   

  1. 江苏省徐州市肿瘤医院药剂科,江苏 徐州 221005; 江苏大学附属徐州医院,江苏 徐州 221005
  • 收稿日期:2012-05-07 出版日期:2012-09-10 发布日期:2015-08-07
  • 作者简介:张红旭,男,主管药师,植物多糖的研究。

Effects of Rhodiola Sachalinensis Polysaccharides on Activity of the Human T Lymphocytes in Vitro and Proliferation of the Human Gastric Cancer Cell in Vitro

  1. Dept of Pharmacy, Xuzhou Cancer Hospital, Jiangsu Xuzhou 221005, China; Affiliated Xuzhou Hospital of Jiangsu University, Jiangsu Xuzhou 221005, China
  • Received:2012-05-07 Online:2012-09-10 Published:2015-08-07

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摘要： 目的研究红景天多糖对体外正常人T淋巴细胞活性和对体外人胃癌细胞增殖的影响。方法采用MTT比色法和体外细胞培养计数法。结果红景天多糖对体外PHA诱导的正常人外周血T淋巴细胞的增殖有显著性促进作用（P <0.05）;红景天多糖对体外人胃癌细胞增殖有显著性抑制作用（P <0.05）,且红景天多糖作用强于香菇多糖（P <0.05）。结论红景天多糖可能是一种免疫增强剂,对胃癌可能有一定防治作用。

关键词: 红景天多糖, T淋巴细胞, 胃癌, 增殖, 促进, 抑制

Abstract: ObjectiveTo investigate the effects of Rhodiola sachalinensis Polysaccharides(RSP) on activity of the human T lymphocytes in vitro and proliferation of the human gastric cancer cell in vitro. MethodsMTT colorimetry assay and in vitro culture cell number count assay were adopted. ResultsThe results show that RSP significantly accelerated the transformation and proliferation of the healthy human peripheral blood T lymphocytes in vitro(P <0.05) and inhibited the proliferation of the human gastric cancer cell in vitro(P <0.05), and what's more, the inhibitory effect of RSP was stronger than that of Lentinan(P <0.05). ConclusionRSP may be an immunoenhancer and have some efficacy on the prevention and cure of gastric cancer.

Key words: Rhodiola sachalinensis Polysaccharides(RSP), T lymphocytes, gastric cancer, proliferation, acceleration, inhabitation