中国药物警戒 ›› 2012, Vol. 9 ›› Issue (9): 542-544.

• 药械安全性研究 • 上一篇    下一篇

274例氯氮平片致不良反应病例分析

梁锦锋1, 王春婷2*, 陈志根1   

  1. 1 浙江省药品不良反应监测中心,浙江 杭州 310012；
    2 国家食品药品监督管理局药品评价中心,北京 100045
  • 收稿日期:2012-06-13 出版日期:2012-09-10 发布日期:2015-08-07
  • 通讯作者: 王春婷,女,副主任药师,药品不良反应监测和评价。E-mail:wangchunting@cdr.gov.cn
  • 作者简介:梁锦锋,男,博士,主管药师,药品不良反应监测与评价。

Analysis of 274 Cases of Adverse Drug Reaction Caused by Clozapine Tablets

LIANG Jin-feng1, WANG Chun-ting2*, CHEN Zhi-geng1   

  1. 1 Zhejiang Center for Adverse Drug Reaction Monitoring, Zhejiang Hangzhou 310012, China;
    2 Center for Drug Reevaluation, SFDA, Beijing 100045, China
  • Received:2012-06-13 Online:2012-09-10 Published:2015-08-07

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摘要： 目的分析274例氯氮平片致不良反应病例报告,探讨氯氮平片致不良反应的特点和规律,为临床安全合理用药提供参考。方法结合文献资料回顾分析274例氯氮平片致不良反应,尤其是严重不良反应进行综合分析。结果氯氮平片致不良反应涉及13个器官-系统损害,主要严重不良反应为以肝功能异常为主要表现的肝胆系统损害、以白细胞减少、粒细胞减少为主要表现的白细胞和网状内皮系统异常等。结论应关注氯氮平所致的严重不良反应,加强用药过程监护,减少药品带来的伤害。

关键词: 氯氮平, 不良反应, 肝损害, 白细胞减少, 粒细胞减少

Abstract: ObjectiveTo probe into the general pattern and characteristics of ADRs induced by clozapine so as to provide references for clinic rational use of clozapine. MethodsCombining the literature, review and retrospectively analyze 274 cases induced by clozapine. ResultsADRs induced by clozapine involve thirteen organ-system damage, the major damages are the damage of the hepatobiliary system and abnormal white blood cells and the reticuloendothelial system, which usually manifest as abnormal liver function, leukopenia and neutropenia. ConclusionIt should be strengthened to observe and evaluate the severe ADRs induced by clozapine. And the medication monitoring of clozapine should be enhanced in order to reduce the injury which the drugs bring.

Key words: clozapine, adverse drug reaction, liver damage, leukopenia, neutropenia