中国药物警戒 ›› 2011, Vol. 8 ›› Issue (5): 260-262.

• 基础研究 • 上一篇    下一篇

龙草颗粒对高血压大鼠血管ET和NO表达的影响

董桂英1, 李泉红1, 张维东2, 王兆朋2, 孙昱1, 江宁1, 秦英1   

  1. 1. 济南市中医医院,山东 济南250012;
    2. 山东省医学科学院基础医学研究所,山东 济南 250001
  • 收稿日期:2015-08-27 修回日期:2015-08-27 出版日期:2011-05-10 发布日期:2015-08-27
  • 作者简介:董桂英,女,主任中医师,硕士研究生导师,高血压及其并发症的中西医结合临床、教学及科研。

The Effects of Long Cao Particles on the Expression of ET and NO in Hypertensive Rats' Vessels

DONG Gui-ying1, LI Quan-hong1, ZHANG Wei-dong2, WANG Zhao-ming2, SUN Yu2, JIANG Ning1, QIN Ying1   

  1. 1. Jinan Chinese Medicine Hospital, Shandong Jinan 250012, China;
    2. Basic Medical Research Institute of Shandong Medical Academy, Shandong Jinan 250001, China
  • Received:2015-08-27 Revised:2015-08-27 Online:2011-05-10 Published:2015-08-27

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摘要： 目的 观察龙草颗粒对高血压大鼠血管ET和NO表达的影响。方法 将高血压大鼠（SHR）分为阳性对照组、龙草颗粒大剂量组、龙草颗粒小剂量组、阴性对照组和 Wistar大鼠组。连续灌胃1个月。采用免疫组织化疗S-P法和原位杂交方法检测血管ET和NO表达。结果 龙草颗粒可使高血压大鼠血管ET下调,高血压大鼠血浆NO表达上调。结论 龙草颗粒可通过调节血管ET及NO表达水平,改善内皮功能而发挥其降压作用。

关键词: 龙草颗粒, 高血压, 内皮素, 一氧化氮

Abstract: Objective To observe the effects of Long Cao Particles on the expression of ET and NO in hypertensive rats' vessels. Methods Divide the spontaneously hypertensive rats(SHR) into such groups as positive, large dose of Long Cao Particles, small dose of Long Cao Particles, negative and wistar. After a month of intragastric administration, test the expression of ET and NO in the vessels by means of immune tissue S-P chemotherapy and hybridization in situ. Results Long Cao Particles can reduce ET and raise the expression of NO in hypertensive rats' vessels. Conclusion By regulating the expression of ET and NO level in vessels, Long Cao Particles can improve the endothelial function and bring high blood pressure down.

Key words: Long Cao Particles, hypertension, ET, NO

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