人参-丹参有效成分及其相关制剂治疗冠心病的研究进展

doi:10.19803/j.1672-8629.20250705

摘要/Abstract

摘要： 目的探讨人参-丹参有效成分及相关制剂治疗冠心病（CAD）的研究进展,为其进一步研究及应用提供参考。方法检索国内外数据库,对人参-丹参有效成分及相关制剂治疗CAD相关研究进行系统梳理,分析其治疗CAD的中医理论基础、药理作用及分子机制。结果 CAD属中医学“胸痹心痛”范畴,针对其“气虚血瘀”之病机,“益气活血”经典药人参（益气）与丹参（活血）配伍治疗CAD效果确切。人参-丹参对CAD发挥治疗作用的主要活性成分为人参皂苷类（如Rg₁、Rb₁等）、丹参酮类和丹酚酸类,这些有效成分及不同形式制剂（包括药对配伍、化合物组合、活性组分配伍及复方制剂）可通过改善心肌能量代谢、修复线粒体功能、抑制炎症反应及抗氧化应激等多重机制,减轻缺血、再灌注及微循环障碍等所致的心肌损伤和心脏功能障碍。结论基于“益气活血”治则的人参-丹参有效成分及相关制剂,通过多成分协同作用,有效改善CAD心脏功能并减轻心肌损伤,具有进一步临床应用和研究价值。

关键词: 益气活血, 人参, 丹参, 冠心病, 胸痹, 心痛

Abstract: Objective To summarize the recent advancements in the treatment of coronary artery disease (CAD) with the active ingredients and formulations of Ginseng-Salvia Miltiorrhiza in order to facilitate subsequent research and clinical applications. Methods Relate literature on treating CAD with the active ingredients and formulations of Ginseng-Salvia Miltiorrhiza was retrieved before the theories concerned, pharmacological effects, and molecular mechanisms of TCM were analyzed. Results CAD was regarded as “chest impediment and heart pain in TCM”, and its pathogenesis was characterized by qi deficiency and blood stasis. Ginseng and Salvia Miltiorrhiza were classic herbs for “invigorating qi and promoting blood circulation” with consistent efficacy and broad clinical applicability. The primary active ingredients of Ginseng responsible for cardiovascular protection were ginsenosides (such as Rg₁, Rb₁, etc), while those of Salvia Miltiorrhiza were tanshinones and phenolic acids. Active ingredients and formulations of Ginseng-Salvia Miltiorrhiza (including herbal pairs, combination of active ingredients, and compound formula) could exert significant cardioprotective effects against myocardial injury caused by ischemia, reperfusion injury, and microcirculatory dysfunction during the progression of CAD by improving myocardial energy metabolism, repairing damaged mitochondria, inhibiting inflammatory factor expressions, and counteracting oxidative stress. Conclusion By “invigorating qi and promoting blood circulation”, the active ingredients and formulations of Ginseng-Salvia Miltiorrhiza can synergistically improve cardiac function and attenuate myocardial injury in CAD.

Key words: Invigorating Qi and Promoting Blood Circulation, Ginseng, Salvia Miltiorrhiza, Coronary Artery Disease, Thoracic Obstruction, Heartache

中图分类号:

R972
R282

白雪, 李雪丽. 人参-丹参有效成分及其相关制剂治疗冠心病的研究进展[J]. 中国药物警戒, 2026, 23(6): 630-635.

BAI Xue, LI Xueli. Research Progress in Active Ingredients of Ginseng and Salvia Miltiorrhiza and Its Therapeutic Effect against Coronary Heart Disease[J]. Chinese Journal of Pharmacovigilance, 2026, 23(6): 630-635.

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https://zgywjj.magtechjournal.com/CN/Y2026/V23/I6/630

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