中国药物警戒 ›› 2025, Vol. 22 ›› Issue (10): 1087-1093.
DOI: 10.19803/j.1672-8629.20250369

• 何首乌质量研究专栏 • 上一篇    下一篇

基于化学成分研究探讨何首乌饮片切制工艺

汪祺1,2, 李妍怡3, 杨颜榕4, 石佳1,*   

  1. 1中国食品药品检定研究院中药民族药检定所,北京 100050;
    2药品监管科学全国重点实验室,北京 102629;
    3北京中医药大学中药学院,北京 102400;
    4沈阳药科大学功能食品与葡萄酒学院,辽宁 沈阳 110016
  • 收稿日期:2025-06-06 出版日期:2025-10-15 发布日期:2025-10-20
  • 通讯作者: *石佳,女,硕士,助理研究员,中药鉴定与其数字化。E-mail: shijia@nifdc.org.cn
  • 作者简介:汪祺,女,博士,研究员,中药质量与安全性评价。
  • 基金资助:
    国家自然科学基金资助项目（82374033）; 药品监管科学全国重点实验室课题（2025SKLDRS0345)

Process of Cutting Polygonum multiflorum Slices Based on Chemical Composition

WANG Qi1,2, LI Yanyi3, YANG Yanrong4, SHI Jia1,*   

  1. 1National Institutes for Food and Drug Control, Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, Beijing 100050, China;
    2State key Laboratory of Drug Regulatory Science, Beijing 102629, China;
    3School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;
    4School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang Liaoning 110016, China
  • Received:2025-06-06 Online:2025-10-15 Published:2025-10-20

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摘要： 目的 考察何首乌饮片不同药用部位主要化学成分含量分布差异,探讨其去头尾两端炮制工艺的必要性。方法 采用液质联用系统测定4个产地市售何首乌饮片中间及两端11种化学成分含量及分布差异。结果 所测定的11个化学成分在何首乌中的分布均为两端含量高于中间含量。其中,2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷（trans-THSG）在头尾的含量为中间部位的1倍以上。此外,大黄素-8-O-β-D-葡萄糖苷和决明酮-8-O-β-D-葡萄糖苷除1个产地外,其余3个产地的样品两端含量也约为中间的2倍。何首乌饮片不同部位,trans-THSG、大黄素-8-O-β-D-葡萄糖苷和决明酮-8-O-β-D-葡萄糖苷分布存在较大差异。结论 何首乌去两端的加工炮制方法可一定程度上降低饮片中trans-THSG、大黄素-8-O-β-D-葡萄糖苷和决明酮-8-O-β-D-葡萄糖苷的含量,继而减少何首乌的肝毒性风险。

关键词: 何首乌, 饮片, 炮制, 化学成分, 2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷, 大黄素-8-O-β-D-葡萄糖苷, 决明酮-8-O-β-D-葡萄糖苷, 质量

Abstract: Objective To investigate the differences in the distribution of main chemical components in different medicinal parts of Polygonum multiflorum decoction pieces, and to explore the applicability of processing techniques for removing the two ends of the plant. Methods A liquid chromatography-mass spectrometry system was used to find out about the differences in the content distribution of eleven chemical components in the middle and at both ends of Polygonum multiflorum decoction pieces sold in four areas of production. Results The distribution of the eleven chemical components measured in Polygonum multiflorum was higher at both ends than in the middle. Among these components, the content of 2,3,5,4 '- tetrahydroxystilbene-2-O-β-D-glucoside (trans-THSG) at either end was twice that of the middle. In addition, the contents of emodin-8-O-β-D-glucoside and quercetin-8-O-β-D-glucoside at either end of the samples from three of the areas of production were almost twice those of the middle. In Polygonum multiflorum decoction pieces of different origins, the distribution of trans-THSG, emodin-8-O-β-D-glucoside and quercetin-8-O-β-D-glucoside was considerably different. Conclusion The processing method-removing both ends of Polygonum multiflorum-can reduce the contents of trans-THSG, emodin-8-O-β-D-glucoside, and quercetin-8-O-β-D-glucoside in the decoction pieces to some extent, thereby lowering the risk of hepatotoxicity of Polygonum multiflorum.

Key words: Polygonum multiflorum, Decoction Pieces, Processing, Chemical Composition, 2,3,5,4 '- tetrahydroxystilbene-2-O-β-D-glucoside, emodin -8-O-β-D-glucoside, quercetin-8-O-β-D-glucoside, Quality

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