中国药物警戒 ›› 2024, Vol. 21 ›› Issue (11): 1232-1237.
DOI: 10.19803/j.1672-8629.20240635

• 生殖功能中医药研究专栏 • 上一篇    下一篇

五子衍宗丸治疗少弱精子症的研究进展

谭天阳1, 唐田2, 刘柘君3, 白雪4,*   

  1. 1中国中医科学院西苑医院康复医学科,北京 100091;
    2中国科学院北京基因组研究所,北京 100101;
    3首都医科大学中医药学院,北京 100069;
    4中国中医科学院医学实验中心,北京市中医药防治重大疾病基础研究重点实验室,北京 100700
  • 收稿日期:2024-08-23 出版日期:2024-11-15 发布日期:2024-11-20
  • 通讯作者: *白雪,女,博士,助理研究员,中药防治生殖系统疾病。E-mail: dr.baixue@hotmail.com
  • 作者简介:谭天阳,男,博士,主治医师,慢性病康复的机制与临床研究。
  • 基金资助:
    国家自然科学基金资助项目（82304767）; 中央级公益性科研院所基本科研业务费专项基金（JJPY2022021和ZZ15-YQ-055）; 中国中医科学院科技创新工程项目（CI2021B017）; 中国中医科学院西苑医院院级师承项目（YJMPSC202437）

Research Progress on Wuzi Yanzong Pill in the Treatment of Oligoasthenospermia

TAN Tianyang1, TANG Tian2, LIU Zhejun3, BAI Xue4,*   

  1. 1Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China;
    2Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center for Bioinformation, Beijing 100101, China;
    3School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China;
    4Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Disease, Beijing 100700, China
  • Received:2024-08-23 Online:2024-11-15 Published:2024-11-20

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摘要： 目的 探讨五子衍宗丸在治疗少弱精子症（OA）的临床效果和作用机制。方法 综述近3年来五子衍宗丸治疗少弱精子症的最新研究进展,包括临床疗效、作用机制及药理学研究。结果 五子衍宗丸可通过多靶点、多途径改善精子质量和数量。主要机制包括抑制氧化应激和细胞凋亡、调节内分泌功能、保护血睾屏障、改善线粒体功能等。此外,五子衍宗丸还可能通过调节肠道菌群、影响基因表达等途径发挥作用。临床研究证实了五子衍宗丸对少弱精子症患者的治疗效果,并探讨了其与其他治疗方法的联合应用的疗效。结论 五子衍宗丸在治疗少弱精子症方面显示出良好的临床效果,但其确切作用机制和临床应用策略仍需进一步深入研究。

关键词: 五子衍宗丸, 少弱精子症, 男性不育, 精子质量, 精子活力, 精子数量

Abstract: Objective Oligoasthenospermia (OA) is a prevalent cause of male infertility, significantly impairing fertility and life quality. The traditional Chinese medicine formula, Wuzi Yanzong Pill, has demonstrated promising efficacy in treating this condition. This article explores the clinical efficacy and mechanism of action of Wuzhi Yanzong Pill in the treatment of oligoasthenozoospermia. Methods This article reviews the latest research progress on the treatment of oligoasthenozoospermia with Wuzhi Yanzong Pill in the past three years, encompassing its clinical effectiveness, mechanisms of action, and pharmacological investigations. Result Studies have shown that Wuzi Yanzong Pill enhances sperm quality and quantity through various targets and pathways. It is primarily achieved by reducing oxidative stress and cellular apoptosis, regulating endocrine functions, protecting the blood-testis barrier, and boosting mitochondrial function. Additionally, the pill is found to influence gut microbiota and affect gene expression. Clinical research supports the therapeutic benefits of Wuzi Yanzong Pill in individuals with oligoasthenospermia and examines its synergistic use with other treatments. Conclusion Wuzhi Yanzong Pill has shown good clinical efficacy in the treatment of oligoasthenozoospermia. However, more comprehensive research is needed to fully understand its mechanisms and refine its clinical application strategies.

Key words: Wuzi Yanzong Pill, Oligoasthenospermia, Male Infertility, Sperm Quality, Sperm Vitality, Sperm Count

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