中药多靶点干预代谢综合征血管内皮损伤研究进展

doi:10.19803/j.1672-8629.20220256

摘要/Abstract

摘要： 代谢综合征（metabolic syndrome, MS）是一组代谢异常聚集发病的临床症候群,发病机制复杂,不及时干预可导致动脉粥样硬化等心脑血管疾病,血管内皮损伤是心脑血管疾病的早期预测因子和主要病理基础。目前西医治疗以针对各组分进行降糖、降脂、降压和抗凝治疗为主,许多药物存在明显的使用禁忌,联合用药存在药物相互作用,可能加重药品不良反应。中医药在整体观念和辨证论治理论指导下,干预MS血管内皮损伤具有多途径、多靶点、作用持久、副作用小的特点。本文对中药治疗MS血管内皮损伤的作用机制进行综述,以期为中医药防治MS血管内皮损伤提供理论依据。

关键词: 代谢综合征, 血管内皮损伤, 中药, 多靶点, 药品不良反应

Abstract: Metabolic syndrome（MS）is a cluster of clinical syndromes of multiple metabolic disorders with complex pathogenesis. It can develop into atherosclerosis and serious cardio-cerebrovascular diseases if quick intervention is impossible. Vascular endothelial injury is an early predictor and the main pathological basis of MS. Western medicine focuses on hypoglycemic, lipid-lowering and hypotensive treatments, so many of these drugs have obvious contraindications, and drug interactions occur in combined medications, which is likely to aggravate adverse drug reactions. Under the guidance of holistic concepts and treatments based on syndrome differentiation theories, traditional Chinese medicine is characterized by multi-component and multiple-target properties, long-lasting efficacy and smaller side effects in the intervention of vascular endothelial injury of MS. This article summarizes the research progress in Chinese herbs in the treatment of vascular endothelial injury in order to provide data for the prevention and treatment of MS-related vascular endothelial injury by TCM.

Key words: metabolic syndrome, vascular endothelial injury, traditional Chinese medicine, multi-target, adverse drug reaction

中图分类号:

R994.11

徐帅, 张玲, 赵玉清, 杨一点, 卞昊宇, 张立平. 中药多靶点干预代谢综合征血管内皮损伤研究进展[J]. 中国药物警戒, 2023, 20(3): 353-359.

XU Shuai, ZHANG Ling, ZHAO Yuqing, YANG Yidian, BIAN Haoyu, ZHANG Liping. Advances in multi-target intervention in vascular endothelial injury in metabolic syndrome by traditional Chinese medicine[J]. Chinese Journal of Pharmacovigilance, 2023, 20(3): 353-359.

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