利奈唑胺片致双膝关节痛1例分析

doi:10.19803/j.1672-8629.20220015

中国药物警戒 ›› 2023, Vol. 20 ›› Issue (2): 221-224.
DOI: 10.19803/j.1672-8629.20220015

利奈唑胺片致双膝关节痛1例分析

吴燕燕¹, 胡雪莲², 淡重辉^3*

¹重庆市妇幼保健院药学部,重庆医科大学附属妇女儿童医院,重庆 401147;
²陆军军医大学第二附属医院药学部,重庆 400037;
³重庆市急救医疗中心药剂科,重庆市第四人民医院,重庆 400013

收稿日期:2022-02-11 出版日期:2023-02-15 发布日期:2023-02-17
通讯作者: ^*淡重辉,男,本科,主管药师,临床医学。E-mail: 283290643@qq.com
作者简介:吴燕燕,女,硕士,主管药师,抗感染临床药理。
基金资助:
重庆市科卫联合医学科研项目（2021MSXM255）

Analysis of one case of double knee joint pain induced by linezolid tablets

WU Yanyan¹, HU Xuelian², DAN Chonghui^3*

¹Pharmacy Department, Chongqing Health Center for Women and Children, Chongqing 401147, China;
²Pharmacy Department, the Second Affiliated Hospital, Army Medical University, Chongqing 400037, China;
³Pharmacy Department, Chongqing Emergeng Medical Center, Chongqiny University Central Hospital, Chongqing 400013, China

Received:2022-02-11 Online:2023-02-15 Published:2023-02-17

摘要/Abstract

摘要： 目的通过分析利奈唑胺致双膝关节痛新的不良反应,为利奈唑胺的临床药学监护提供借鉴。方法以1名39岁女性椎间神经鞘瘤切除术后感染脓肿分枝杆菌患者为例,分析患者服用利奈唑胺片0.6 g（口服,每日2次）+克拉霉素片0.5 g（口服,每日2次）+莫西沙星片0.4 g（口服,每日1次）导致双膝关节痛的原因,并采用诺氏评分表评估可能引起关节痛的药物。结果患者双膝关节痛可能与利奈唑胺有关,考虑为利奈唑胺导致的新的不良反应。结论药师除了关注利奈唑胺导致的骨髓抑制如白细胞降低外,还应关注利奈唑胺所致的新的不良反应,做好药学监护。

关键词: 利奈唑胺, 双膝关节, 疼痛, 药品不良反应, 脓肿分枝杆菌, 病例报告

Abstract: Objective To analyze new adverse reactions-double knee joint pain-caused by linezolid in order to provide reference for related clinical pharmaceutical care. Methods The causes of double knee joint pain in a 39-year-old female patient were analyzed who had suffered mycobacterium abscess infection after resection of intervertebral schwannoma and taken oral linezolid tablets 0.6 g, oral clarithromycin tablets 0.5 g, and oral moxifloxacin tablets 0.4 g. Drugs that might have caused joint pain were identified using the Naranjo’s assessment scale. Results The pain and discomfort of knee joint in both legs were attributed to linezolid, and considered new adverse reactions caused by linezolid. Conclusion Pharmacists should be alert to new adverse reactions caused by linezolid and give high-quality pharmaceutical care while watching out for such marrow suppression as leukopenia caused by linezolid.

Key words: linezolid, double knee joint, pain, adverse drug reactions, mycobacterium abscess, case report

中图分类号:

R994.11

吴燕燕, 胡雪莲, 淡重辉. 利奈唑胺片致双膝关节痛1例分析[J]. 中国药物警戒, 2023, 20(2): 221-224.

WU Yanyan, HU Xuelian, DAN Chonghui. Analysis of one case of double knee joint pain induced by linezolid tablets[J]. Chinese Journal of Pharmacovigilance, 2023, 20(2): 221-224.

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利奈唑胺片致双膝关节痛1例分析

Analysis of one case of double knee joint pain induced by linezolid tablets

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