中国药物警戒 ›› 2022, Vol. 19 ›› Issue (3): 313-316.
DOI: 10.19803/j.1672-8629.2022.03.18

• 安全与合理用药 • 上一篇    下一篇

2型糖尿病降糖药不良反应及联合用药情况分析

向玉芳1,2, 孙辉3, 陈月1,2, 王宁生1,2, 罗世书3, 张智3, 冯变玲1,2,*   

  1. 1西安交通大学药学院,陕西 西安 710061;
    2西安交通大学药品安全与政策研究中心,陕西 西安 710061;
    3陕西省食品药品监督检验研究院,陕西 西安 710065
  • 收稿日期:2020-05-06 出版日期:2022-03-15 发布日期:2022-03-16
  • 通讯作者: *冯变玲,女,博士,教授,药事管理。E-mail：fengbl@mail.xjtu.edu.cn
  • 作者简介:向玉芳,女,硕士,药事管理。
  • 基金资助:
    国家社科基金项目（18XGL019）

Medication safety and combined medication in patients with type 2 diabetes mellitus

XIANG Yufang1,2, SUN Hui3, CHEN Yue1,2, WANG Ningsheng1,2, LUO Shishu3, ZHANG Zhi3, FENG Bianling1,2,*   

  1. 1School of Pharmacy, Xi'an Jiaotong University, Xi'an Shaanxi 710061, China;
    2The Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an Shaanxi 710061, China;
    3Food and Drug Supervision Institute of Shaanxi Province, Xi'an Shaanxi 710065, China;
  • Received:2020-05-06 Online:2022-03-15 Published:2022-03-16

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摘要： 目的 探讨2型糖尿病患者（T2DM）药品不良反应（ADR）及联合用药方案。方法 选取陕西省2015年1月1日至2019年12月31日间所有T2DM患者ADR报告,分析基本情况、ADR临床表现及影响因素、联合用药情况。结果 共收集到陕西省T2DM患者ADR报告2 050例,主要造成胃肠系统损害、代谢营养障碍和皮肤附件损害,女性、高龄、合并用药是造成ADR的常见因素,二甲双胍的二联用药在所有联合用药的病例报告中数量最多。结论 重点关注ADR发生的高危人群,包括女性、高龄患者和多种药物联合使用者,并慎重选择联用药物。

关键词: 2型糖尿病, 降糖药, 不良反应, 联合用药

Abstract: Objective To investigate the current incidence of adverse drug reactions (ADR) and combined drug regimens for patients with type 2 diabetes mellitus (T2DM). Methods All the ADR reports of T2DM patients in Shaanxi Province collected between 2015 and 2019 were selected to analyze the basic data, clinical manifestations and influencing factors of ADR, and the combined use of drugs. Results A total of 2 050 cases of ADR related to T2DM patients in Shaanxi Province were collected, including damage to the gastrointestinal system, metabolic and nutritional disorders and damage to the skin and its accessories. Femininity, old age and combined drug use were the common causes of ADR, and combined drug use with metformin accounted for the highest proportion of all cases of combined drug use. Conclusion Clinicians should focus their attention on high-risk groups of ADR, including women, elderly patients and users of multiple drug combinations, and select the proper combination of drugs.

Key words: type 2 diabetes mellitus, hypoglycemic drugs, adverse drug reaction, drug combination

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