中国药物警戒 ›› 2020, Vol. 17 ›› Issue (2): 114-116.
DOI: 10.19803/j.1672-8629.2020.02.10

• 安全与合理用药 • 上一篇    下一篇

吡非尼酮胶囊致肌肉酸痛分析

刘蕾1, 王永2, 钱效森2, 王攀1, 孙瑞芳1*   

  1. 1民航总医院药剂科,北京 100123;
    2民航总医院呼吸内科,北京 100123
  • 收稿日期:2019-02-18 修回日期:2020-06-22 出版日期:2020-02-15 发布日期:2020-02-26
  • 通讯作者: *孙瑞芳,女,主任药师,药事管理与临床药学。E-mail:ruifangsun@sohu.com
  • 作者简介:刘蕾,女,副主任药师,药事管理与临床药学。

Analysis of Muscle Ache Induced by Pirfenidone Capsules

LIU Lei1, WANG Yong2, QIAN Xiaosen2, WANG Pan1, SUN Ruifang1*   

  1. 1Department of Pharmacy, Civil Aviation General Hospital, Beijing 100123, China;
    2Department of Respiratory Medicine, Civil Aviation General Hospital, Beijing 100123, China
  • Received:2019-02-18 Revised:2020-06-22 Online:2020-02-15 Published:2020-02-26

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摘要： 目的 探讨吡非尼酮胶囊导致肌肉酸痛的发生机制及治疗措施。方法 分析1例吡非尼酮胶囊导致肌肉酸痛患者的诊疗经过,通过文献分析,阐述吡非尼酮胶囊与肌肉酸痛不良反应的因果关系、发生机制和处理意见的要点。结果与结论 吡非尼酮胶囊导致的肌肉酸痛症状与吡非尼酮剂量增加有关,对开展吡非尼酮治疗过程中的新的药学监护点提供理论依据,治疗上应根据患者的具体情况采用减量、停药或调整治疗方案等积极措施。

关键词: 吡非尼酮, 肌肉酸痛, 不良反应

Abstract: Objective To explore the mechanism and treatment of muscle ache caused by pirfenidone. Methods The diagnosis and treatment process of one patient with muscle ache caused by pirfenidone were analyzed. Based on literature review, the causal relationships between pirfenidone and muscle ache, the mechanism of its occurrence and the focus of treatment were outlined. Results and Conclusion The symptoms of muscle ache caused by pirfenidone are related to the increased dose of pirfenidone, which can remind clinicians to pay attention to the new pharmaceutical care points in the process of treatment with pirfenidone. Doctors can take such active measures as reducing the dosage, stopping the medication or adjusting the treatment plan according to the condition of patients.

Key words: pirfenidone, muscle ache, adverse drug reaction

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