中国药物警戒 ›› 2020, Vol. 17 ›› Issue (2): 111-113.
DOI: 10.19803/j.1672-8629.2020.02.09

• 安全与合理用药 • 上一篇    下一篇

注射用头孢哌酮舒巴坦致急性凝血功能障碍分析

兰博1, 李佳2, 周甘平1*   

  1. 1广西壮族自治区江滨医院药学部,广西 南宁 530021;
    2中山大学附属第一医院药学部,广东 广州 510080
  • 收稿日期:2019-02-18 修回日期:2020-06-22 出版日期:2020-02-15 发布日期:2020-02-26
  • 通讯作者: *周甘平,男,主任药师,临床药学。E-mail:573073996@qq.com
  • 作者简介:兰博,男,主管药师,临床药学。
  • 基金资助:
    广西医疗卫生适宜技术开发与推广应用项目(S2018002)

Analysis of Acute Coagulation Dysfunction Induced by Cefoperazone Sulbactam Sodium for Injection

LAN Bo1, LI Jia2, ZHOU Ganping1*   

  1. 1Department of Pharmacy, Jiangbin Hospital of Guangxi, Nanning GuangXi 530021, China;
    2Department of Pharmacy, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Guangdong 510080, China
  • Received:2019-02-18 Revised:2020-06-22 Online:2020-02-15 Published:2020-02-26

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摘要： 目的 探讨注射用头孢哌酮舒巴坦致急性凝血功能障碍的处置措施。方法 分析1例头孢哌酮舒巴坦致急性凝血功能障碍患者的诊疗经过,结合文献检索,探索头孢哌酮舒巴坦诱发急性凝血功能障碍的机制及应对措施。结果 患者静脉使用头孢哌酮舒巴坦后第4天 突发凝血功能障碍,立即停用,改用哌拉西林他唑巴坦抗感染治疗,并肌内注射维生素K1,患者凝血指标逐步下降,并于停药后第4天恢复正常。结论 头孢哌酮舒巴坦导致的急性凝血功能障碍应立即停药,在静脉滴注新鲜冰冻血浆的基础上肌内注射维生素K1。

关键词: 头孢哌酮舒巴坦, 不良反应, 凝血功能障碍, 维生素K1

Abstract: Objective To explore the treatments of acute coagulation dysfunction by cefoperazone sulbactam sodium. Methods A case who diagnosed with acute coagulation dysfunction due to cefoperazone sulbactam sodium was analyzed, we were trying to explore the treatments by medical literature retrieval. Results The patient was diagnosed as dysfunction of blood coagulation due to cefoperazone sulbactam sodium and the drug was stopped the same day, change with IV infusion of piperacillin tazobactam sodium and intramuscular injection of vitamin K1. The coagulation index of the patient decreased gradually and returned to normal on the 4th day after drug withdrawal. Conclusion Acute coagulation dysfunction caused by cefoperazone sulbactam sodium should stop infusing immediately, and intramuscular injection of vitamin K1 must be given with infusion of fresh frozen plasma.

Key words: cefoperazone sulbactam sodium, adverse reaction, coagulation disorders, vitamin K1

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