Abstract: Objective To explore the characteristics and general features of adverse reactions induced by the fat soluble vitamin injections(Ⅰ)、(Ⅱ), and provide reference for rational clinical use of drugs. Methods To retrieval journals database from January 2001 to May 2014 by using keywords which are "fat soluble vitamin injections(Ⅰ) and (Ⅱ)" and "adverse reaction" reported in the literatures, then these results should be analyzed statistically. Results This paper includes 21 literatures and 23 cases. The fat soluble vitamins involve 2 varieties which are fat soluble vitamin (Ⅰ)and fat soluble vitamin(Ⅱ).The constituent ratio for patients aged 50 and above is the largest, accounting for 47.82%. The sex ratio of adverse reactions is 1: 1.09. Among adverse reactions, the allergic shock caused by the allergic reaction was the most(16 cases). The adverse reaction occurs mostly in the 1 ~ 15min, accounting for 56.52%. The adverse reaction involves the skin, respiratory, circulatory, nervous, digestive and other systems. Conclusion Adverse reaction for most of the fat soluble vitamins are allergic reactions (especially anaphylactic shock). Adverse reactions have nothing to do with the sex, relate with the age, history of allergies, and medication time. Therefore, we must ask the allergy history clinically, and pay attention to adverse reactions, especially adverse reactions in 15 minutes. When adverse reactions occur, we should deal with the problems in time and ensure security.

Key words: fat soluble vitamin injection(Ⅰ), fat soluble vitamin injection(Ⅱ), adverse reaction, literature analysis