Abstract: Objective To investigate the compatible stability of nitroprusside sodium for injection(SNP) when mixed with sodium chloride injection. Methods SNP was prepared into solution according to clinical use. The stability of SNP solution was studied in different environment and at different time, including appearance, pH value, insoluble particle, ultraviolet-visible absorption and SNP content. Results SNP solutions of sodium chloride injection were stable for 26 hours after preparation in shading circumstances at 20℃ or 35℃.Under the direct incandescent lamp without lightproof covering or shading circumstances, the solution was very unstable. Conclusion In the dark condition, SNP was stable within 26h after mixing with sodium chloride injection.

Key words: sodium nitroprusside, HPLC, compatibicity, stability