Abstract: Objective To evaluate the effect of antimicrobial prescription by review on medical records and improve comment methods. Methods The percentage of antimicrobial use, combined use rate, antimicrobial use density (AUD), pathogenic test rate on therapeutic use antimicrobial, AUD of each clinical department and AUD constituent ratios of different generation cephalosporinsins from October 2014 to April 2015 were analyzed. Results The usage percentage, combined use rate and AUD of antimicrobial decreased from 61.48%, 42.81% and 55.23 DDDs to 57.82%, 35.52% and 50.84 DDDs, respectively. Fall ratio is 5.95%,17.03% and 7.95% in turn. Pathogenic test rate on therapeutic medication increased from 28.41% to 38.80%, rise ratio is 36.57%. AUD constituent ratios of the first and second generation cephalosporins increased from 2.54% to 30.75%.Statistics by department, 15 of 22 clinical departments have different decline of AUD. Conclusion Antimicrobial prescription review on medical records has received good results for promoting rational use of antimicrobial in our hospital.

Key words: antimicrobial agents, prescription comment, medical records