Study on Refining Process Optimization of Shuxuening Injection

Chinese Journal of Pharmacovigilance ›› 2015, Vol. 12 ›› Issue (9): 542-546.

Study on Refining Process Optimization of Shuxuening Injection

ZHAO Yu-xin^{1, 2}, GAO Hui-qin^{1, 3}, ZHANG Hao-jun¹, LI Xiang-ming¹, WANG Wen-peng¹, SUN Sheng-bin^{1, 2}, JIANG Guo-zhi^{1, 3}, LI Zhen-jiang^{1, 3}

1.Shineway Pharmaceutical Group Co., Ltd., Hebei Shijiazhuang 051430, China;
2.Hebei Province Engineering Research Center for TCM Injection， Hebei Shijiazhuang 051430, China;
3.State-local Joint Engineering Laboratory of New Drugs Development Technology for TCM Injection, Hebei Shijiazhuang 051430, China

Received:2015-08-08 Revised:2015-12-07 Online:2015-09-08 Published:2015-12-07

Abstract

Abstract: Objective To optimize the refining process of Shuxuening injection by polyamide chromatography column. Methods Through the orthogonal experiment design method in the polyamide chromatography column, observing velocity, alcohol elution volume and ethanol concentration which can change the transfer rate of component of Shuxuening injection. Results The polyamide chromatography velocity, alcohol elution volume and ethanol concentration are the main factors that can affect the component of Shuxuening injection. Conclusion The parameters of optimal refining process parameters are that, the flow rate is 0.2 times the volume of polyamide column chromatography column per hour, alcohol elution volume is 9 times extract's weight, ethanol concentration is 75%.

Key words: Shuxuening injection, process reseach, Ginkgo biloba extract, polyamide

CLC Number:

R965

ZHAO Yu-xin, GAO Hui-qin, ZHANG Hao-jun, LI Xiang-ming, WANG Wen-peng, SUN Sheng-bin, JIANG Guo-zhi, LI Zhen-jiang. Study on Refining Process Optimization of Shuxuening Injection [J]. Chinese Journal of Pharmacovigilance, 2015, 12(9): 542-546.

References

[1] 王怡红,张征林,宋苇，等.改性聚酰胺层析柱的性能及其在银杏黄酮类化合物提取中的应用[J].植物资源与环境,1999,8(1):11-15.
[2] 郁青,谭卫红,陈祥.超滤在纯化银杏叶黄酮甙中的应用[J].林业科技通讯，1997,(2):21-22.
[3] 徐志红,肖泽仪,李磊，等.超滤深度提纯银杏黄酮[J].精细化工,2004,21(2) :112.
[4] 冯晓萍,查忠勇,王槐三.银杏叶黄酮提取工艺研究现状[J].四川化工与腐蚀控制,2002,5(2): 13-16.
[5] 陈冲,王文丰,孙来九.从银杏叶中提取银杏黄酮的最佳工艺条件研究[J]. 精细化工, 1997,14(6): 21-24.
[6] 江德安.叶用银杏的研究进展[J].林业科技,2003,7(4)：44-47.
[7] 李会银.舒血宁注射液在临床中应用以及溶媒的选择问题[J].现代中西医结合杂志,2014,23(23)：2619-2622.
[8] 向芳.舒血宁注射液对于急性脑梗死的临床治疗分析[J].中国中医药资讯,2012,4(3):270.
[9] 国家食品药品监督管理局.舒血宁注射液[S]. 北京：国家药品标准，WS3-B-3707-98-2004-2012.
[10] 刘新义,张水寒,杨永华.聚酰胺吸附和纯化蒲黄总黄酮的工艺研究[J].湖南中医药大学学报,2008,28(4):41-43.
[11] 尹秀莲,游庆红,魏晓春.聚酰胺层析法分离纯化银杏叶总黄酮的研究[J].医药世界,2007,(S1):43-44.
[12] 樊从照,朱军,李晓瑾等.香紫苏花序与种子挥发油提取工艺的研究[J].中国现代中药,2013,15(5):398-401.
[13] 臧晓韵,赵琪,胡海峰.马黛茶中绿原酸水提取工艺研究[J]. 中国现代中药，2015,17(1):47-50.
[14] 黄忠钧,张艳,孟宪生，等.参草通脉颗粒三七总皂苷提取工艺优化研究[J]. 中国现代中药，2013,15(5):403-405.
[15] 刘弘，王俊杰，张玲昂，等.加权综合评分法优化心得宁口服液提取工艺的研究[J]. 中医学报，2014,29(1):76-77.
[16] 薛扬,吴唯.聚酰胺树脂的层析分离应用[J].化工新型材料, 2005,33(4):50-53.
[17] 包琦瑛. 聚酰胺树脂在分离提取领域中的应用[J]. 浙江中医药大学学报，2009,33(4):611-612.