Abstract: Objective To evaluate the antiinflammatory, analgesic and antipruritic effects of Zijin detoxicating suppository (ZJDS). Methods To observe the antiinflammatory effect of ZJDS, the tests of ear swelling and skin capillary permeability induced by xylene and the test of rat granuloma were carried out. To investigate analgesic effect, hot plate and acetic acid induced writhing tests in mice were performed. To discover antipruritic effect of ZJDS, pruritus of guinea pig was induced by phosphoric acid histamine and pruritus of mice was induced by dextran. Results ZJDS showed obvious inhibition effect on mice ear swelling and abdominal skin capillary permeability increase, and significantly reduced the weight of cotton pellet granuloma. ZJDS can increase the pain and itch threshold of mice, and reduce the writhing times and the number of itching. Conclusion ZJDS possessed the pharmacological effects of antiinflammation, analgesia and antipruritus.

Key words: Zijin detoxicating suppository, cervicitis, antiinflammation, analgesia, antipruritus