A 26 Weeks Oral Toxicity of Extracts of Phyllanthus urinaria L. in Beagle Dogs
JIA Qing-Wen1, XIN Ju-yun2, DAI Xue-dong1
1 Shandong Institute of Pharmaceutical Industry, Shandong Jinan 250033 China; 2 Qingzhou Tranditional Chinese Medical Hospital, Shandong Qingzhou 262500, China
JIA Qing-Wen, XIN Ju-yun, DAI Xue-dong. A 26 Weeks Oral Toxicity of Extracts of Phyllanthus urinaria L. in Beagle Dogs[J]. Chinese Journal of Pharmacovigilance, 2012, 9(5): 259-262.
[1] 张兰珍,郭亚建,涂光忠,等.叶下珠化学成分研究[J].中国中药杂志,2000,25(10):615-617. [2] P.S.Venkateswwaran, I.Millman, and B.S.Blamberg. Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis viruses: in vitro and in vivo studies[J]. PNAS, 1987, 84: 274-278. [3] Myung Hua Kong, Tae Soon Kim, Chun Geon Park. Preventive sffects of Phyllanthus urinaria extract on paw edema in adjuvant- induced arthritis rats[J]. FASEB J, 2008, 22: 889. [4] 玉顺子.叶下珠及其制剂药理作用及临床应用研究进展[J].中国药业,2010,19(7):87-88. [5] 王越,沈连忠,李波.临床前研究中肝损伤的临床病理指标的选择及意义[J].中国药事,2009,23(8):813-816. [6] 王敏.中药致药源性肝损害[J].中国误诊学杂志,2006,6(7)1388- 1390.