Chinese Journal of Pharmacovigilance ›› 2012, Vol. 9 ›› Issue (2): 69-70.

• Orginal Article • Previous Articles     Next Articles

Compatibility of Polyene Phosphatidylcholine and 10 Drugs in Common Use

LIU Xiao-hong1,ZHANG Ming-sheng2   

  1. 1 Department of PHarmacy, The Third Hospital Affiliated to Anhui Medical University, Hefei First People's Hospital, Anhui Hefei, 230061, China;
    2 Department of PHarmacy, The First Affiliated Hospital of Anhui College of TCM, Anhui Hefei, 230031, China
  • Received:2011-07-17 Online:2012-02-10 Published:2015-08-10

PDF (PC)

465

Abstract: Objective To observe the compatibility of polyene phosphatidylcholine and 10 other drugs in common usage. MethodsTo mix isopyknic polyene phosphatidylcholine glucose injection with 10 other drugs and pharmic glucose injections and observe the clarity of the mixtures and test their pH values; to directly mix isopyknic polyene phosphatidylcholine injection and 8 other injections and observe their clarity. ResultsMixtures of polyene phosphatidylcholine glucose injection with vitamin B6 ant glucose injection and aminomethyl benzoic acid and glucose injection are muddy and their PH values are lower than 6.5; Mixtures of isopyknic polyene phosphatidylcholine and ribavirin, vitamin C, metoclopramide dihydrochloride and vitamine K1 are muddy. ConclusionPolyene phosphatidylcholine is incompatible with vitamin B6, aminomethylbenzoic acid, ribavirin, vitamin C, metoclopramide dihydrochloride and vitamin K1.

Key words: polyene phosphatidylcholine, compatible stability, common