Clinical Treatment and Medications for Monkeypox with Vulva and Perianal Lesions

doi:10.19803/j.1672-8629.20240046

Abstract

Abstract: Objective To analyze the clinical characteristics of cases of monkeypox mostly with vulva and perianal lesions and the clinical efficacy of integrated Chinese and Western medicine. Methods The clinical data of 43 patients with vulvar and perianal lesions hospitalized and discharged from Chengdu Public Health Clinical Medical Center between June 29, 2023 and July 31, 2023 was retrospectively analyzed. Results A total of 56 monkeypox patients were admitted in this space of time, 43 of whom had vulvar and perianal lesions, All these patients were males, with a mean age of (31.37 ± 5.47) years (ranging from 19 to 42 years), Among these patients, 35 (81.40%) were MSM, six (13.95%) were bisexual, 16 (37.21%) were infected with HIV, 33 (76.74%) started with perineal and perianal rashes, and 27 had more than 10 herpes. Levels of C reactive protein were significantly elevated [(30.43 ± 25.23) mg·L^-1] Their hospital stay averaged (8.98 ± 2.72) days after treatment. The average absorption time of blister fluid was (4.44 ± 1.86) days while complete shedding of the scab skin took (8.95 ± 2.73) days. Nineteen of these cases (44.19%) left scars. A comparison of clinical data between HIV-and non-HIV-infected patients showed that HIV patients had more herpes, higher C-reactive protein levels, lower CD3⁺ CD4⁺ T lymphocyte count [(431.40 ± 220.67) vs (719.58 ± 274.04), P<0.01], and a higher proportion of antibiotic use (15/1 vs 18/9, P <0.05). Conclusion Individuals engaging in homosexual or bisexual behavior account for a high proportion among current monkeypox patients, with initial rashes around the perineum and perianal areas. Patients with HIV infections tend to have more severe conditions and recover more slowly than non-HIV infected individuals. For patients presenting with genital or perianal rashes or ulcers, monkeypox screening is recommended. Based on patients' conditions, appropriate medication plans should be formulated. Monkeypox can be effectively treated by combining traditional Chinese and Western medicine.

Key words: Monkeypox, Vulvar, Anal, Men Who Have Sex with Men, HIV, AIDS

CLC Number:

BAO Lei, LI Jike, TANG Rong, ZHANG Ling, CHENG Deyun, ZHANG Wei, LUO Mei. Clinical Treatment and Medications for Monkeypox with Vulva and Perianal Lesions[J]. Chinese Journal of Pharmacovigilance, 2024, 21(12): 1350-1356.

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https://zgywjj.magtechjournal.com/EN/Y2024/V21/I12/1350

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