[1] HE YZ, CHEN XT, CHEN JL, et al.Changes and progress of AIDS antiviral therapy drugs in China[J]. Guangdong Medical Journal(广东医学), 2023, 44(2): 157-160. [2] OH KS, SEO GH, CHOI HK, et al.Effect of single tablet regimen on prescription trends for treatment-naïve patients with HIV/AIDS in Korea[J]. Sci Rep, 2022, 12(1): 2031. [3] TANG LL, HUANG HP.Impurity control for compound preparation and its impact on product optimization[J]. Modern Chemical Research(当代化工研究), 2023(19): 188-190 [4] CHEN GL, ZHANG L, CHEN P, et al.The status and prospect of research and development of drug combinations[J]. Chinese Journal of New Drugs(中国新药杂志), 2016, 25(19): 2205-2210. [5] FOKA FET, MUFHANDU HT.Current ARTs, virologic failure, and implications for AIDS management: a systematic review[J]. Viruses, 2023, 15(8): 1732. [6] CAO XJ, CAO J, QI H, et al.HIV-1 primary drug resistance at home and abroad[J]. Journal of Modern Medicine & Health(现代医药卫生), 2022, 38(24): 4226-4230. [7] Acquired Immunodeficiency Syndrome and Hepatitis C Professional Group, Society of Infectious Diseases, Chinese Medical Association, Chinese Center For Disease Control and Prevention. Chinese AIDS diagnosis and treatment guidelines (2024 Edition)[Z]. Chinese Journal of Infectious Diseases(中华传染病杂志), 2024. [8] FU ZP, KANG DW, LIU XY, et al.New progress of target-based anti-AIDS drugs[J]. Progress in Pharmaceutical Sciences(药学进展), 2020, 44(9): 681-697. [9] AMBLARD F, PATEL D, MICHAILIDIS E, et al.HIV nucleoside reverse transcriptase inhibitors[J]. Eur J Med Chem, 2022, 240: 114554. [10] GULICK RM, RIBAUDO HJ, SHIKUMA CM, et al.Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection[J]. N Engl J Med, 2004, 350(18): 1850-1861. [11] ZHU YJ, MEI PF, XU QQ, et al.Quantitative study of HIV-1 RNA in plasma and HIV-1 DNA in cells of patients treated with highly effective antiviral therapy[J]. Chinese Preventive Medicine(中国预防医学杂志), 2022, 23(3): 167-170. [12] EDWARDS Z, INGOLD CJ, AZMAT CE.Zidovudine[M]. Treasure Island: StatPearls Publishing LLC, 2024. [13] MA HL, LI JW, LIU A, et al.Clinical observation of antiviral treatment of HIV based on zidovudine and lamivudine tablets[J]. Chinese Journal of AIDS & STD(中国艾滋病性病), 2016, 22(8): 605-607. [14] PORTSMOUTH SD, SCOTT CJ.The renaissance of fixed dose combinations: Combivir[J]. Ther Clin Risk Manag, 2007, 3(4): 579-583. [15] HUANG WY, GUO SY, ZHANG XD.Clinical efficacy, medicinal mechanism and adverse reactions of classical and novel AIDS antiviral drugs[J]. China Journal of Pharmaceutical Economics(中国药物经济学), 2022, 17(1): 51-55. [16] ASTUTI N, MAGGIOLO F.Single-tablet regimens in HIV therapy[J]. Infect Dis Ther, 2014, 3(1): 11-17. [17] DEEKS ED, PERRY CM.Efavirenz/emtricitabine/tenofovir disoproxil fumarate single-tablet regimen (Atripla®): a review of its use in the management of HIV infection[J]. Drugs, 2010, 70(17): 2315-2338. [18] DEJESUS E, YOUNG B, MORALES-RAMIREZ JO, et al.Simplification of antiretroviral therapy to a single-tablet regimen consisting of efavirenz, emtricitabine, and tenofovir disoproxil fumarate versus unmodified antiretroviral therapy in virologically suppressed HIV-1-infected patients[J]. J Acquir Immune Defic Syndr, 2009, 51(2): 163-174. [19] MUCCINI C, CASTAGNA A.A four-drug combination oral tablet of darunavir, cobicistat, emtricitabine, and tenofovir alafenamide for the treatment of HIV-1 infection in adults[J]. Expert Rev Anti Infect Ther, 2023, 21(11): 1167-1176. [20] DEEKS ED.Darunavir: a review of its use in the management of HIV-1 infection[J]. Drugs, 2014, 74(1): 99-125. [21] JIANG TY, LI B, WANG W, et al.Research progress of darunavir in treatment of HIV infection[J]. Chinese Journal of AIDS & STD(中国艾滋病性病), 2020, 26(7): 783-786, 790. [22] ERON JJ, ORKIN C, GALLANT J, et al.A week-48 randomized phase-3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patients[J]. Aids, 2018, 32(11): 1431-1442. [23] SCARSI KK, HAVENS JP, PODANY AT, et al.HIV-1 Integrase inhibitors: a comparative review of efficacy and safety[J]. Drugs, 2020, 80(16): 1649-1676. [24] SCOTT L J.Dolutegravir/Lamivudine single-tablet regimen: a review in HIV-1 infection[J]. Drugs, 2020, 80(1): 61-72. [25] DE CLERCQ E, ZHANG Z, HUANG J, et al.Biktarvy for the treatment of HIV infection: progress and prospects[J]. Biochem Pharmacol, 2023, 217: 115862. [26] BAI J, ZHANG C.Application and research progress of Bienpranol in the treatment of acquired immune deficiency syndrome[J]. Clinical Medication Journal(临床药物治疗杂志), 2021, 19(3): 20-25. [27] CENTO V, PERNO CF.Two-drug regimens with dolutegravir plus rilpivirine or lamivudine in HIV-1 treatment-naïve, virologically-suppressed patients: latest evidence from the literature on their efficacy and safety[J]. J Glob Antimicrob Resist, 2020, 20: 228-237. [28] LLIBRE JM, HUNG CC, BRINSON C, et al.Efficacy, safety, and tolerability of dolutegravir-rilpivirine for the maintenance of virological suppression in adults with HIV-1: phase 3, randomised, non-inferiority SWORD-1 and SWORD-2 studies[J]. Lancet, 2018, 391(10123): 839-849. [29] RHEE SY, KASSAYE SG, BARROW G, et al.HIV-1 transmitted drug resistance surveillance: shifting trends in study design and prevalence estimates[J]. J Int AIDS Soc, 2020, 23(9): e25611. [30] MOHAMED H, GURROLA T, BERMAN R, et al.Targeting CCR5 as a component of an HIV-1 therapeutic strategy[J]. Front Immunol, 2021, 12: 816515. [31] NAKATA H, MAEDA K, DAS D, et al.Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s[J]. Sci Rep, 2019, 9(1): 4828. [32] HEREDIA A, LATINOVIC O, GALLO RC, et al.Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1[J]. Proc Natl Acad Sci USA, 2008, 105(51): 20476-20481. [33] FAIVRE N, VEROLLET C, DUMAS F.The chemokine receptor CCR5: multi-faceted hook for HIV-1[J]. Retrovirology, 2024, 21(1): 2. [34] GULICK RM, SU Z, FLEXNER C, et al.Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-infected, treatment-experienced patients: AIDS clinical trials group 5211[J]. J Infect Dis, 2007, 196(2): 304-312. [35] AIAMKITSUMRIT B, DAMPIER W, MARTIN-GARCIA J, et al.Defining differential genetic signatures in CXCR4- and the CCR5-utilizing HIV-1 co-linear sequences[J]. PLoS One, 2014, 9(9): e107389. [36] KUFEL WD.Antibody-based strategies in HIV therapy[J]. Int J Antimicrob Agents, 2020, 56(6): 106186. [37] JACOBSON JM, LALEZARI JP, THOMPSON MA, et al.Phase 2a study of the CCR5 monoclonal antibody PRO 140 administered intravenously to HIV-infected adults[J]. Antimicrob Agents Chemother, 2010, 54(10): 4137-4142. [38] ELLWANGER JH, KAMINSKI VL, CHIES JA.What we say and what we mean when we say redundancy and robustness of the chemokine system - how CCR5 challenges these concepts[J]. Immunol Cell Biol, 2020, 98(1): 22-27. [39] SUN L.Design, synthesis and bioactivity evaluation of novel HIV-1 capsid protein inhibitors and RNase H inhibitors[D]. Jinan: Shandong University, 2021. [40] SEGAL-MAURER S, DEJESUS E, STELLBRINK HJ, et al.Capsid inhibition with lenacapavir in multidrug-resistant HIV-1 infection[J]. N Engl J Med, 2022, 386(19): 1793-1803. [41] GUPTA SK, BERHE M, CROFOOT G, et al.Lenacapavir administered every 26 weeks or daily in combination with oral daily antiretroviral therapy for initial treatment of HIV: a randomised, open-label, active-controlled, phase 2 trial[J]. Lancet HIV, 2023, 10(1): e15-e23. [42] PAIK J.Lenacapavir: first approval[J]. Drugs, 2022, 82(14): 1499-1504. |