Abstract: Objective To analyze WHO Expert Committee's report on reviewing of tramadol for International Control, find out drug surveillance's data is a key factor which determines whether or not to recommend international control of substances. Methods US FDA and WHO website were retrieved and review data sheet of tramadol conducted by WHO Expert Committee are researched. Results During 1992 and 2006, tramadol had been submitted to the Expert Committee four times to determine whether or not to recommend under international control. According to the data subjected by countries, Committee considered that, even after a recent major increase in the extent of its use because of its therapeutic usefulness, tramadol continues to show a low level of abuse. Hence, the Committee concluded that there was not sufficient evidence to recommend international control of tramadol. Conclusion Surveillance of post-marketing psychoactive substances plays role in placing the substances under control.

Key words: psychoactive substance, tramadol, drug control, surveillance, WHO