Research Progress on Toxicity of Pyrrolizidine Alkaloids

Abstract

Abstract: Pyrrolizidine alkaloids (PAs) are a group of natural components which widely distributed in plants all over the world. Some of them have anti-tumor and anti-bacterial effects. However, most PAs exert multiple toxicities after metabolic activation, while toxicities of pyrrolizidine alkaloid N-oxides (PANO) have been reported in recent years. They attack multiple organs, induce carcinomas and cause developmental toxicity. This review updated the research on mechanism and effect of PAs toxicity as well as detoxification during recent years.

Key words: pyrrolizidine alkaloids, metabolic activation, toxicity

CLC Number:

R961

SUN Xiaoxiang, XIANG E, QIU Shuaikai, WANG Hui, GUO Yu. Research Progress on Toxicity of Pyrrolizidine Alkaloids[J]. Chinese Journal of Pharmacovigilance, 2019, 16(2): 76-80.

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