Abstract: Objective To compare the similarities and differences of the instruction contents among injections with same name from different manufacturers, and to propose reasonable suggestion in order to make the medicine specification a reasonable guide to the patient's medication. Methods Collected and analyzed 40 groups' injection instructions with the same ingredients from different manufacturers. Results 15 groups of instruction are basically similar, 5 groups are different in adverse reactions, 6 groups of instruction are different in contraindications, 4 groups of instruction are different in warnings and precautions, 5 groups of instruction are different in drug interactions, 5 groups of instruction are different in pregnant women and nursing mothers usage, 5 groups of instruction are different in children's usage, and 4 groups of instruction are different in the senior usage. Conclusion Injections with same components have different instruction from different manufactures. This should cause attention from drug administration departments, medical institutions and the medical staff, and improve administration.

Key words: drug instruction, rational safe use, investigation and analysis