Chinese Journal of Pharmacovigilance ›› 2017, Vol. 14 ›› Issue (10): 590-593.

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Effect of Paroxetine on Postoperative Psychological State and Pain Mediators in Eldly Fractured Patients with Anxiety and Depression

XIE Yi-jing1，ZHANG Peng2,   

  1. 1.Department of orthopaedics, MeiTan General Hospital, Beijing 100028, China;
    2.Department of Urology, MeiTan General Hospital, Beijing 100028, China
  • Received:2017-04-06 Revised:2017-11-30 Online:2017-10-20 Published:2017-11-30

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Abstract: Objective To investigate the effect of paroxetine on psychological status, pain score and pain mediators after surgery in the elderly patients with anxiety and depression after fracture. Methods From April 2015 to December 2016, a total of 60 eldly patients with anxiety and depression after fracture were enrolled in the study. According to the sequence of hospital admissions, all patients were divided into two groups: treatment group (n=30) and control group (n=30). All patients were given the conventional therapy and nursing. The treatment group recevied paroxetine on the basis of control group. Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) were used to evaluate mood disorders change. Visual Analogue Scale (VAS) was applied to measure pain. The levels of 5-hydroxytryptamine (5-HT), nitric oxide (NO) and prostaglandin E2 (PGE2) were determined by enzyme linked immunosorbent assay (ELISA). The changes of psychological state, pain scale and serum pain mediators before and 28 d after treatment were observed and compared in both groups. Nursing satisfaction level was evaluated before discharging. Results Before treatment, there were no statistical difference in HAMA,HAMD and VAS score between two groups (P ＞0.05). After treatment, HAMA, HAMD and VAS score in the two groups were significantly lower than before treatment (all P ＜0.01). After treatment, HAMA,HAMD and VAS score in the treatment group were significantly lower than those in control group, respectively (P ＜0.05 or 0.01). Before treatment, there were no statistical differences in serum 5-HT, NO, PGE2 levels between two groups (P＞0.05). After treatment, serum 5-HT, NO, PGE2 levels in both groups were significantly lower than before treatment (all P＜0.01). After treatment, serum 5-HT, NO, PGE2 levels in the treatment group were significantly lower than those in control group, respectively (P ＜0.05 or 0.01). Satisfaction on nursing service in the treatment group was higher than that in control group (P ＜0.05). Conclusion Paroxetine can effectively relieve anxiety and depression, reduce pain and the expression of pain mediators, improve nursing satisfaction.

Key words: fracture, anxiety and depression, paroxetine, pain mediators

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