Comparison of Blood Pressure, Pulse Pressure, Heart Rate and Adverse Reaction Between Different Dosage of Etomidate-induced Anesthesia in Adolescents

Abstract

Abstract: Objective To observe and compare the differences of blood pressure, pulse pressure, heart rate and adverse reactions at different doses of etomidate during anesthesia induction in adolescents. Methods 150 cases patients with general anesthesia in our hospital were collected from February 2013 to April 2016, the age of 17 to 40 years old, according to the different dose and induced drugs were randomly divided into 5 groups: E3 (etomidate 300 g·kg^-1), E4 (etomidate 400 g·kg^-1), E5 (etomidate 500 g·kg^-1), E6 (etomidate 600 g·kg^-1), P (propofol 2 mg·kg^-1). The changes of systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), Brain electric dual frequency index (BIS) and adverse reactions at T0, T1, T2,T3, T4 and T5 timing were observed and recorded. Results Compared with T0, the patients of BIS were significantly decreased in the five groups after induction, (P<0.05), SBP, DBP, MAP of E6 group were significantly decreased (P<0.05), after intubation, the SBP, DBP, MAP of E3 group were significantly increased, E4 and E5 group were relatively stable. Compared with the P group, BIS, SBP, DBP and MAP in the E3 group were significantly higher than those in the P group (P <0.05), and HR was significantly higher than that of P group at T1 (P < 0.05).The BIS, DBP and MAP of E6 group were significantly lower than those of P group (P <0.05), SBP was significantly lower than that of P group at T1 (P <0.05), HR and P group were no difference (P> 0.05). The difference of BIS, DBP and HR between E4 group and P group was not significant (P> 0.05). SBP was significantly higher at T1, T3, T4 and T5 than that in group P (P <0.05), MAP at T1, T4 and T5 was significantly higher than that of P group (P <0.05). There was no significant difference between E5 group and P group (P> 0.05). Conclusion The concentration of etomidate within the scope of 400 μg·kg^-1~500 μg·kg^-1has good effect in adolescents anesthesia induction, and the indicators change is relatively stable.

Key words: adolescents, different doses, etomidate, induced anesthesia, hemodynamics

CLC Number:

WANG Lei, Wang chun-xue. Comparison of Blood Pressure, Pulse Pressure, Heart Rate and Adverse Reaction Between Different Dosage of Etomidate-induced Anesthesia in Adolescents[J]. Chinese Journal of Pharmacovigilance, 2017, 14(5): 313-316.

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