Abstract: Objective To explor the clinical effect and safty in the treatment of postherpetic neuralgia (PHN) by different administration route of extracts from rabbit skin inflamed by vaccinia virus for injection (ERSIVVI). Methods PHN patients were selected for study, all patients were divided into parapharyngeal administration group (PA group) and intravenous administration group (IV group) , which has 45 patients, The PA group treated by paravertebral administration with 45 mL ERSIVVI (3mL: 3.6 IU) + 195 mL 0.9% NS with 2 mL·h^-1, and the IV group treated by ERSIVVI 9 mL intravenous infusion. Likert pain scale and QS sleep index were used to evaluate pain and sleep improvement before treatment, 1 day after treatment, at discharge, and after discharge. Results 90 cases of PHN patients were selected for study, which had been treated in our hospital during Sep 2014 to Nov 2016 and were divided into two group randomly, each group of 45 cases. Likert pain scores of two groups of patients one day after treatment, at discharge and one month after discharge were significant lower than before treatment (P <0.05). Compared with the IV group, the Likert pain score of PA group one day after treatment was significantly decreased (P <0.05). QS sleep index score of two groups of patients one day after treatment, at discharge and one month after discharge were significant higher than before treatment (P <0.05). Compared with the IV group, the QS sleep index score of PA group,after 1day of treatment was significantly increased (P<0.05). The clinical efficacy of the PA group was significant higher than IV group, the significant efficiency of PA group was significant higher (P<0.05). During treatment periods, there was one case of dizziness, nausea and slight increase of blood pressure in the IV group. After 15 min of withdrawal, the above symptoms were relieved. In the course of subsequent treatment the patients did not show any of the above symptoms. Conclusion The efficacy of ERSIVVI in the treatment of herpes zoster by paravertebral injection is clear, with few adverse reactions.

Key words: extracts from rabbit skin inflamed by vaccinia virus for injection, post herpetic neuralgia, observation