Effectiveness Study on Global Trigger Tool in Detecting Adverse Drug Events for Children

Abstract

Abstract: Objective To evaluate the effectiveness and popularization value of global trigger tool(GTT) in detecting adverse drug event(ADE) for children.Methods Six hundred cases medical records of inpatient were randomly selected from December 2014 to December 2015, then were retrospectively reviewed according to GTT method. The positive triggers- related situations were further reviewed to identify or exclude ADE. All ADEs were evaluated for severity classification and involved system-organs.Results There were 576 medical records, and 326 patients (56.60%, 326/576) with at least one trigger positive. Twenty-two out of the 26 triggers were positive. Among them, the proportion of “antidiarrheal / microecological drugs/oral metronidazole/vancomycin/norvancomycin” was the highest (24.85%) . 107 ADE cases were determined by GTT method, and the detection rate was 18.58% (107/576). The damage classifications of ADE were concentrated as “mild harm” and “moderate harm”. The number of organs involved was the highest (50.00%) in the gastrointestinal system.Conclusion GTT plays a positive role in preventing adverse drug events, while it still needs to be optimized.

Key words: adverse drug event, global trigger tool, trigger, pediatric patients

CLC Number:

R969.3

WU Juan, HU Yi-bing, XU Ni. Effectiveness Study on Global Trigger Tool in Detecting Adverse Drug Events for Children[J]. Chinese Journal of Pharmacovigilance, 2017, 14(2): 119-122.

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