Chinese Journal of Pharmacovigilance ›› 2017, Vol. 14 ›› Issue (2): 90-94.

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Review on the Immunization Strategy in Polio Post-eradication Era and Comparison of the Safety of Polio Vaccination Programs

XIONG Wei-yi ,DONG Duo*   

  1. Center for Drug Reevaluation, CFDA, Beijing 10045, China
  • Received:2017-03-10 Revised:2017-03-10 Online:2017-02-20 Published:2017-03-10

Abstract: Oral poliomyelitis attenuate live vaccine (OPV) has been routinely used in most countries’ national immunization programs (NIPs) since the middle of 1960s and is generally recognized as the major factor for the success of the Global Polio Eradication Initiative. However, in 2015, to tackle the rising disease burden of vaccine associated paralytic poliomyelitis (VAPP), the most serious adverse event following immunization of OPV, the World Health Organization launched global withdrawal of the type 2 component of OPV and urged all the member states to include at least one dose of inactived poliovirus vaccine (IPV) in NIPs. This paper summarizes the rationale and progress of immunization strategy transition in polio post-eradication era and compared the safety of different polio vaccination programs.

Key words: poliomyelitis, poliomyelitis vaccine, vaccine associated paralytic poliomyelitis

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