Research Advance on Pharmacological Effects and Metabolism of Fufangdanshen Dripping Pills

Abstract

Abstract: Objective To summarize the current states of pharmacological effects and metabolic research about Fufangdanshen dripping pills. Methods By combing articles published at home and abroad in recent 20 years, the research progress of the effective components and quality control methods, metabolism and pharmacological effects were summarized, the effects of Fufangdanshen dripping pills on drug metabolizing enzymes were described specially. Results and Conclusion Chemical constituents and quality control methods of Fufangdanshen dripping pills have been maturely studied. Its main pharmacological effects are enhancing cell viability, improving tissue ischemia, inhibiting platelet aggregation and so on. Most of the main monomer components in the dropping pills inhibit CYP450s, only a very small part has an induction effect, and the overall effect of the preparation is not a simple addition. It is a difficult and hot topic to further expound the action mechanisms about the effects of Fufangdanshen dripping pills on drug metabolizing enzymes.

Key words: Fufangdanshen dripping pill, metabolism, pharmacological effect

CLC Number:

R965

CHANG Hong, LI Zheng-guo, YANG Qing-guo, WU Shi-fu. Research Advance on Pharmacological Effects and Metabolism of Fufangdanshen Dripping Pills[J]. Chinese Journal of Pharmacovigilance, 2016, 13(11): 682-685.

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