Abstract: Objective To achieve the rational application of Shenmai injections through active monitoring and to analyze irrational application in daily practices, so as to establish the effective guidance for the basic-grade hospitals at 4 city areas of Guangdong province. Methods A method of prospective case series study was designed to inquire total of 2 402 patients who were injected Shenmai injections in 13 basic-grade hospitals at 4 city areas of Guangdong province. Results Statistic analysis indicated that the level of irrational application of Shenmai injections in the grade I hospitals 82.64% was significantly higher χ2=6.66, P=0.0099 than that in the grade II hospitals 76.45%. The major performances of irrational applications included: injections with over doses, incorrect selections of solvent, over-high concentrations and improper combinations of drugs. Over dose application rate of Shenmai injections in hospitals of the grade I and the grade II were 74.21% and 47.10%, respectively. Conclusion The irrational application of Shenmai injections in hospitals at 4 city areas of Guangdong province is a serious problem. Practical guidance in rational use of the drug and the guide for doctors in primary hospitals should be strengthened.

Key words: Shenmai injection, irrational application, statistic analysis